Rabbit Polyclonal NF2 Antibody

Neurofibromatosis type 2 (NF2) is a rare genetic disorder caused by mutations in the *NF2* gene, located on chromosome 22q12.2. This gene encodes the tumor suppressor protein merlin (moesin-ezrin-radixin-like protein), also known as schwannomin, which regulates cell proliferation, adhesion, and cytoskeletal organization. Loss-of-function mutations in *NF2* lead to uncontrolled cell growth, resulting in benign tumors of the nervous system, such as vestibular schwannomas, meningiomas, and ependymomas. NF2 antibodies are immunological tools developed to detect and study the expression, localization, and functional roles of the merlin protein in both normal and pathological conditions. These antibodies are widely used in research to investigate merlin’s interaction with signaling pathways (e.g., Hippo, PI3K/AKT) and its tumor-suppressive mechanisms. Clinically, NF2 antibodies aid in diagnosing NF2-related tumors through immunohistochemical staining, where loss of merlin expression often correlates with *NF2* mutations. Additionally, they are explored in therapeutic contexts, such as validating gene therapy or targeting downstream pathways in NF2-deficient cancers. The development of high-specificity NF2 antibodies remains critical for advancing molecular diagnostics and understanding the pathogenesis of NF2-associated tumors.