| WB | 咨询技术 | Human,Mouse,Rat Monkey |
| IF | 咨询技术 | Human,Mouse,Rat Monkey |
| IHC | 1/100-1/300 | Human,Mouse,Rat Monkey |
| ICC | 技术咨询 | Human,Mouse,Rat Monkey |
| FCM | 咨询技术 | Human,Mouse,Rat Monkey |
| Elisa | 1/40000 | Human,Mouse,Rat Monkey |
| Aliases | NTN1; NTN1L; Netrin-1; Epididymis tissue protein Li 131P |
| Entrez GeneID | 9423; |
| WB Predicted band size | 75kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat Monkey |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Netrin-1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于Netrin-1抗体的代表性文献摘要(虚拟示例，仅供参考)：
1. **文献名称**：*Netrin-1 blockade inhibits tumor growth and metastasis in triple-negative breast cancer*
**作者**：Akirav, E.M. et al.
**摘要**：研究通过特异性中和Netrin-1抗体，证明阻断Netrin-1与其受体UNC5A的相互作用可抑制三阴性乳腺癌小鼠模型的肿瘤生长和转移，并增强化疗敏感性。
2. **文献名称**：*Anti-Netrin-1 antibodies improve recovery in experimental autoimmune encephalomyelitis*
**作者**：Manocha, G.D. et al.
**摘要**：在多发性硬化症小鼠模型中，使用Netrin-1抗体降低中枢神经系统的炎症反应，促进少突胶质细胞再生，缓解神经功能缺损。
3. **文献名称**：*Netrin-1 neutralization reduces cardiac ischemia-reperfusion injury by limiting leukocyte infiltration*
**作者**：López-Benito, S. et al.
**摘要**：通过抗体中和Netrin-1.显著减少心肌缺血再灌注损伤后的中性粒细胞浸润，改善心脏功能并缩小梗死面积。
4. **文献名称**：*Netrin-1 promotes colorectal cancer angiogenesis through endothelial Unc5B receptors*
**作者**：Lejmi, E. et al.
**摘要**：研究发现Netrin-1通过结合血管内皮细胞受体Unc5B促进肿瘤血管生成，使用特异性抗体阻断后可抑制结直肠癌小鼠模型的血管新生和肿瘤进展。
(注：以上文献为示例，实际引用需核实真实文献信息。)
Netrin-1 is a secreted laminin-related protein that plays a critical role in axon guidance during neural development, acting as a chemotropic cue to direct axon growth and cell migration. It interacts with receptors such as DCC (deleted in colorectal cancer) and UNC5H to regulate neuronal pathfinding, angiogenesis, and tissue morphogenesis. Beyond development, Netrin-1 is implicated in cancer progression, inflammation, and vascular remodeling, where its overexpression often correlates with tumor invasiveness, metastasis, and resistance to apoptosis.
Antibodies targeting Netrin-1 are essential tools for studying its biological functions and therapeutic potential. These antibodies enable the detection, quantification, and localization of Netrin-1 in tissues and biofluids, facilitating research into its role in diseases like cancer, neurodegenerative disorders, and cardiovascular conditions. In therapeutic contexts, anti-Netrin-1 antibodies are explored for their ability to block Netrin-1/receptor interactions, thereby inhibiting pro-survival signaling in cancer cells or modulating immune responses.
Recent studies highlight their potential in combination therapies, particularly in cancers with Netrin-1 dependency. Robust validation of these antibodies ensures specificity for applications such as Western blotting, immunohistochemistry, and functional assays, underscoring their dual utility in basic research and drug development.
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