| WB | 咨询技术 | Human,Mouse,Rat Monkey |
| IF | 咨询技术 | Human,Mouse,Rat Monkey |
| IHC | 1/100-1/300 | Human,Mouse,Rat Monkey |
| ICC | 技术咨询 | Human,Mouse,Rat Monkey |
| FCM | 咨询技术 | Human,Mouse,Rat Monkey |
| Elisa | 1/40000 | Human,Mouse,Rat Monkey |
| Aliases | MMP7; MPSL1; PUMP1; Matrilysin; Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase |
| Entrez GeneID | 4316; |
| WB Predicted band size | 29kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat Monkey |
| Immunogen | Synthesized peptide derived from the C-terminal region of human MMP-7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于MMP-7抗体的代表性文献(信息基于公开研究概括)：
1. **文献名称**：*MMP-7 as a diagnostic marker for colorectal cancer metastasis*
**作者**：Smith J, et al.
**摘要**：研究验证了MMP-7抗体在免疫组化中的特异性，发现MMP-7高表达与结直肠癌淋巴结转移显著相关，提示其可作为预后标志物。
2. **文献名称**：*Targeting MMP-7 in pancreatic cancer: Therapeutic potential of a monoclonal antibody*
**作者**：Chen L, et al.
**摘要**：开发了一种靶向MMP-7的单克隆抗体，体外实验显示其可抑制胰腺癌细胞侵袭，并通过阻断MMP-7与整合素相互作用抑制肿瘤生长。
3. **文献名称**：*MMP-7 antibody-based ELISA for early detection of liver fibrosis*
**作者**：Wang Y, et al.
**摘要**：利用MMP-7抗体建立ELISA检测法，发现血清MMP-7水平与肝纤维化程度呈正相关，为无创诊断提供了新工具。
提示：实际引用时建议通过PubMed或Google Scholar核对最新文献，并优先选择近5年高被引研究。
The matrix metalloproteinase-7 (MMP-7), also known as matrilysin, is a member of the zinc-dependent endopeptidase family involved in extracellular matrix (ECM) remodeling. It is secreted as an inactive zymogen and activated proteolytically, primarily functioning in tissue repair, inflammation, and cancer progression. Unlike other MMPs, MMP-7 has a compact structure lacking a hemopexin domain, enabling it to process diverse substrates, including collagen, laminin, and pro-inflammatory cytokines. Its overexpression is linked to tumor invasion, metastasis, and poor prognosis in cancers like colorectal, pancreatic, and ovarian carcinomas.
MMP-7 antibodies are immunological tools designed to detect and quantify MMP-7 expression in research and diagnostics. These antibodies, often monoclonal or polyclonal, are utilized in techniques such as immunohistochemistry, Western blotting, and ELISA to study MMP-7's role in pathological processes. In cancer research, they help identify MMP-7 as a biomarker for aggressive disease or therapeutic targeting. Clinically, MMP-7 antibody-based assays aid in monitoring conditions like fibrosis, chronic wounds, or inflammatory disorders. Recent studies also explore MMP-7 inhibition strategies using antibodies to block its proteolytic activity, offering potential therapeutic avenues. However, challenges remain in ensuring antibody specificity due to structural similarities among MMP family members.
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