| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | CAVII |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于L-type Ca²⁺通道γ7亚基(CACNG7)抗体的3篇参考文献的简要总结(注：文献为模拟示例，实际引用需根据真实研究调整)：
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1. **文献名称**：*"Characterization of a Novel Anti-CACNG7 Antibody for Detecting L-type Calcium Channel Complexes in Cardiac Tissue"*
**作者**：Smith A et al.
**摘要**：本研究开发并验证了一种高特异性兔多克隆抗体，靶向L型钙通道γ7亚基(CACNG7)。通过免疫印迹和免疫组化证实其在心脏组织中的表达，并揭示γ7亚基与α1C亚基的共定位，提示其在调节心肌钙电流中的作用。
2. **文献名称**：*"The Role of γ7 Subunit in Neuronal L-type Calcium Channel Trafficking: Insights from Knockdown and Antibody-Based Inhibition"*
**作者**：Johnson R & Lee S.
**摘要**：利用特异性抗γ7抗体阻断其功能，发现γ7亚基对海马神经元L型钙通道的膜定位至关重要。抗体阻断导致钙内流减少，影响突触可塑性，提示γ7亚基在神经退行性疾病中的潜在病理机制。
3. **文献名称**：*"Monoclonal Antibody Against CACNG7 Reveals Differential Expression in Alzheimer’s Disease Models"*
**作者**：Tanaka K et al.
**摘要**：通过生成小鼠单克隆抗体，研究γ7亚基在阿尔茨海默病模型中的表达变化。结果显示，脑组织内γ7蛋白水平显著下降，与淀粉样斑块沉积相关，提示其可能作为疾病生物标志物。
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**注**：上述内容为模拟生成，实际文献需通过学术数据库(如PubMed、Web of Science)检索关键词“CACNG7 antibody”“L-type calcium channel gamma subunit”等获取。建议结合具体研究需求验证文献可靠性。
The L-type calcium channel gamma-7 subunit (CACNG7) is a member of the voltage-gated calcium channel (VGCC) auxiliary gamma subunit family, which modulates the trafficking and biophysical properties of Cav1 (L-type) channels. These channels are critical for calcium-dependent processes in excitable cells, including muscle contraction, neurotransmitter release, and gene regulation. The gamma-7 subunit, encoded by the CACNG7 gene, is predominantly expressed in the brain, where it interacts with pore-forming alpha-1 subunits (e.g., Cav1.2/CACNA1C) to influence channel kinetics, surface expression, and sensitivity to pharmacological agents.
Research on gamma-7 antibodies has been driven by interest in understanding L-type channel regulation in neurological and cardiovascular disorders. Dysregulation of L-type channels is implicated in epilepsy, neuropathic pain, and cardiac arrhythmias. Antibodies targeting CACNG7 are valuable tools for studying subunit-specific roles in channel complexes, protein-protein interactions, and tissue distribution. For example, immunohistochemical studies using gamma-7 antibodies have revealed its localization in hippocampal neurons, suggesting roles in synaptic plasticity.
Commercially available gamma-7 antibodies are typically developed in rabbits or mice using peptide antigens derived from conserved regions of the human or rodent protein. Validation often includes Western blotting, immunofluorescence, and knockout controls. Challenges include cross-reactivity with other gamma subunits (e.g., gamma-2. gamma-3) due to sequence homology, necessitating careful experimental design. Current applications span basic research on calcium signaling mechanisms and translational studies exploring biomarkers or therapeutic targets in channelopathies.
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