| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MAST3; KIAA0561; Microtubule-associated serine/threonine-protein kinase 3 |
| Entrez GeneID | 23031; |
| WB Predicted band size | 143kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the C-terminal region of human MAST3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是模拟生成的3篇关于MAST3抗体的参考文献示例(注：实际文献可能需要通过学术数据库验证)：
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1. **标题**: *MAST3 regulates mitochondrial dynamics and apoptosis in glioblastoma*
**作者**: Zhang Y, et al.
**摘要**: 研究揭示了MAST3激酶通过调控线粒体分裂蛋白DRP1的磷酸化影响胶质母细胞瘤细胞凋亡。文中使用MAST3特异性抗体进行Western blot和免疫荧光实验，证实其在高侵袭性肿瘤细胞中的过表达。
2. **标题**: *Interaction of MAST3 with Tau protein in Alzheimer's disease models*
**作者**: Patel R, et al.
**摘要**: 探讨MAST3与Tau蛋白的相互作用及其在阿尔茨海默病中的病理意义。通过免疫共沉淀(Co-IP)和MAST3抗体验证了两者的直接结合，并发现MAST3敲减可减少Tau过度磷酸化。
3. **标题**: *MAST3 knockout mice exhibit synaptic plasticity deficits*
**作者**: Lee S, et al.
**摘要**: 利用MAST3基因敲除小鼠模型，结合抗体免疫组化分析，发现MAST3缺失导致海马区突触可塑性受损，提示其在神经发育中的关键作用。
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**建议**：可通过PubMed或Google Scholar搜索 **"MAST3 antibody"** 或 **"MAST3 kinase function"** 获取真实文献，并关注抗体应用场景(如Western blot、IHC等)。部分研究可能涉及疾病机制或信号通路调控。
MAST3 (Microtubule-Associated Serine/Threonine Kinase 3) is a member of the MAST kinase family, characterized by a conserved kinase domain and a PDZ-binding motif. It plays roles in cellular signaling, cytoskeletal organization, and neuronal development. MAST3 antibodies are essential tools for studying its expression, localization, and function in biological systems. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect MAST3 in tissues or cultured cells.
Research suggests MAST3 interacts with various signaling pathways, including those linked to neurotransmitter receptors and microtubule dynamics, implicating it in neurological processes and disorders. Aberrant MAST3 expression or activity has been explored in contexts such as neurodevelopmental conditions, cancer, and synaptic plasticity. Antibodies targeting specific epitopes (e.g., N-terminal or kinase domains) help dissect its post-translational modifications or protein-protein interactions. Commercial and custom MAST3 antibodies vary in specificity; validation via knockout controls or siRNA knockdown is critical to ensure reliability. Recent studies also highlight MAST3's potential role in immune regulation and metabolic pathways, broadening its biomedical relevance. Overall, MAST3 antibodies remain pivotal for advancing understanding of its physiological and pathological mechanisms.
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