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Rabbit Polyclonal Lfc Antibody

  • 中文名: Lfc抗体
  • 别    名: ARHGEF2; KIAA0651; LFP40; Rho guanine nucleotide exchange factor 2; Guanine nucleotide exchange factor H1; GEF-H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40
货号: IPDX43164
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000 Human,Mouse,Rat

产品详情

AliasesARHGEF2; KIAA0651; LFP40; Rho guanine nucleotide exchange factor 2; Guanine nucleotide exchange factor H1; GEF-H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40
Entrez GeneID9181;
WB Predicted band size111kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenSynthesized peptide derived from human Lfc around the non-phosphorylation site of S885.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是基于假设性情景提供的3篇关于“LFC抗体”的参考文献示例(注:LFC可能指某类特定抗体或抗原,此处为虚构示例,实际文献需通过学术数据库查询):

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**1. 文献名称**: *Development and Characterization of a Novel LFC-Specific Monoclonal Antibody for Immunohistochemical Applications*

**作者**: Smith A, et al.

**摘要**: 本研究开发了一种针对LFC蛋白(假设为某细胞标记物)的高特异性单克隆抗体,验证了其在石蜡包埋组织中的免疫组化适用性。实验显示该抗体在乳腺癌样本中特异性识别LFC抗原,灵敏度优于现有商用抗体。

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**2. 文献名称**: *LFC Antibody-Mediated Neutralization of Pathogenic Autoantigens in Rheumatoid Arthritis*

**作者**: Chen L, et al.

**摘要**: 研究探讨了抗LFC抗体在类风湿性关节炎中的作用机制,发现其通过中和患者血清中异常表达的LFC抗原,抑制促炎因子释放。动物模型显示该抗体可减轻关节炎症,提示潜在治疗价值。

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**3. 文献名称**: *Cross-Species Reactivity of Anti-LFC Antibodies: Implications for Comparative Immunology*

**作者**: Gupta R, et al.

**摘要**: 评估了抗LFC抗体在小鼠、人类和灵长类动物中的交叉反应性,发现其保守表位识别能力。该抗体在跨物种蛋白功能研究中展现应用潜力,但需注意部分种属特异性差异。

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**实际建议**:

若需真实文献,请核实“LFC”的全称(如是否为**Lymphocyte Function Correlator**或某基因缩写),并通过PubMed或Google Scholar检索。可尝试关键词组合:`"LFC antibody" AND [应用领域,如cancer/autoimmunity]`,或联系领域专家明确术语定义。

背景信息

Lfc antibody targets the Lfc protein (also known as ARHGAP25), a Rho GTPase-activating protein (GAP) primarily expressed in hematopoietic cells. Discovered in the late 1990s, Lfc regulates cytoskeletal dynamics by inactivating Rho GTPases like Rac and Cdc42. which are critical for cell motility, adhesion, and immune responses. Structurally, Lfc contains a GAP domain, a pleckstrin homology (PH) domain for membrane association, and a SH3 domain mediating protein-protein interactions. Its role in immune cell function, particularly in leukocyte migration and phagocytosis, has linked it to inflammatory diseases and cancer metastasis. Lfc antibodies are essential tools for detecting protein expression, localization, and activity in studies exploring immune regulation, cancer biology, and vascular development. Researchers also utilize these antibodies to investigate Lfc's tumor-suppressive effects in certain cancers and its interactions with signaling pathways like PI3K. The development of specific Lfc antibodies has advanced mechanistic insights into Rho GTPase-mediated cellular processes and potential therapeutic targets.

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