| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | LAMC3; Laminin subunit gamma-3; Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma |
| Entrez GeneID | 10319; |
| WB Predicted band size | 170kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Laminin γ-3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Laminin γ-3抗体的3篇示例文献(内容为模拟概括，仅供参考)：
1. **文献名称**: *Laminin γ-3 chain as a novel target for tumor diagnosis*
**作者**: Smith A, et al.
**摘要**: 研究揭示了Laminin γ-3在多种实体瘤(如乳腺癌和肺癌)中的高表达，并开发了特异性单克隆抗体用于组织样本的免疫组化检测，表明其可作为潜在的肿瘤标志物。
2. **文献名称**: *Role of Laminin γ-3 in neuronal development revealed by antibody-based perturbation*
**作者**: Zhang L, et al.
**摘要**: 通过抗Laminin γ-3抗体的功能阻断实验，发现该蛋白在小鼠大脑皮层神经元迁移和突触形成中起关键作用，提示其与神经发育疾病的相关性。
3. **文献名称**: *Characterization of a polyclonal antibody against human Laminin γ-3 for extracellular matrix studies*
**作者**: Tanaka K, et al.
**摘要**: 报道了一种高亲和力兔源多克隆抗体的制备与验证，该抗体成功应用于Western blot和免疫荧光技术，揭示了Laminin γ-3在皮肤基底膜中的特异性分布。
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**备注**：实际文献需通过PubMed、Google Scholar等平台检索(关键词：Laminin gamma-3 antibody, LAMC3 function)。部分研究可能涉及抗体在癌症转移、组织再生或疾病机制中的具体应用。
Laminin γ-3 (LAMC3) is a subunit of laminins, a family of extracellular matrix glycoproteins critical for tissue organization, cell adhesion, and signaling. Specifically, the γ-3 chain combines with α and β subunits (e.g., α3. β3) to form laminin-332 (formerly laminin-5) and laminin-333. which are essential for epithelial basement membrane integrity, wound healing, and cell migration. LAMC3 is prominently expressed in skin, lung, and neural tissues, with roles in development and tissue repair. Dysregulation of laminin-332/333 is linked to pathologies like cancer progression, epidermolysis bullosa, and fibrosis.
Laminin γ-3 antibodies are immunological tools designed to detect and study the expression, localization, and function of the γ-3 subunit. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to visualize laminin-332/333 distribution in tissues or cultured cells. In research, they help investigate γ-3’s involvement in tumor invasion (e.g., upregulated in certain carcinomas), epithelial-stromal interactions, and neural development. Commercially available as monoclonal or polyclonal variants, these antibodies are validated for specificity against conserved epitopes. Recent studies also explore their potential in therapeutic targeting, such as blocking cancer metastasis or enhancing regenerative processes. Proper controls are essential to avoid cross-reactivity with other laminin γ chains (e.g., γ-1. γ-2). Overall, LAMC3 antibodies remain vital for dissecting extracellular matrix biology and its implications in disease mechanisms.
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