| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | LAMA4; Laminin subunit alpha-4; Laminin-14 subunit alpha; Laminin-8 subunit alpha; Laminin-9 subunit alpha |
| Entrez GeneID | 3910; |
| WB Predicted band size | 203kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the Internal region of human Laminin α-4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是3-4篇关于Laminin α-4抗体的相关文献示例(文献信息及摘要内容为模拟概括，非真实文献)：
---
1. **"Laminin α4 Antibody Blocks Angiogenesis in Tumor Models"**
*作者：Patton B.L. et al.*
**摘要**：研究通过特异性抗Laminin α4抗体抑制肿瘤血管生成，发现抗体可阻断内皮细胞黏附，减少小鼠模型中肿瘤血管形成，提示其潜在抗肿瘤治疗价值。
2. **"Role of Laminin α4 in Inflammatory Cell Migration: Insights from Antibody-Based Inhibition"**
*作者：Durbeej M. et al.*
**摘要**：利用抗Laminin α4抗体探究其在炎症反应中的作用，发现抗体抑制中性粒细胞迁移至炎症部位，表明Laminin α4是炎症细胞外基质信号的关键调控因子。
3. **"Characterization of a Novel Monoclonal Antibody Against Laminin α4 for Tissue Staining"**
*作者：Sasaki T. et al.*
**摘要**：开发并验证了一种高特异性抗Laminin α4单克隆抗体，适用于免疫组化和Western blot，揭示了Laminin α4在肌肉和神经组织基底膜中的分布特征。
4. **"Laminin α4 Deficiency and Antibody Rescue in Vascular Development"**
*作者：Thyboll J. et al.*
**摘要**：通过基因敲除小鼠模型结合抗体功能补偿实验，证明Laminin α4对胚胎血管发育至关重要，抗体干预可部分恢复血管异常表型。
---
注：以上文献名称及内容为示例性概括，实际文献需通过PubMed、Google Scholar或专业数据库检索确认。
Laminin α-4 is a subunit of laminins, a family of heterotrimeric glycoproteins essential for basement membrane structure and function. Laminins consist of α, β, and γ chains, with the α-4 chain (encoded by *LAMA4*) combining with β and γ partners to form specific isoforms like laminin-411 (α4β1γ1) and laminin-421 (α4β2γ1). These isoforms are critical in vascular development, tissue repair, and angiogenesis, influencing cell adhesion, migration, and signaling through interactions with integrins and other receptors.
Laminin α-4 antibodies are tools designed to detect, quantify, or localize the α-4 subunit in biological samples. They are widely used in research to study its role in physiological processes, such as endothelial cell behavior and vascular remodeling, as well as pathological conditions, including cancer metastasis, fibrosis, and cardiovascular diseases. These antibodies are validated for techniques like Western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. Specific applications include investigating α-4 expression patterns in tissues, its dysregulation in tumors, or its contribution to extracellular matrix remodeling during injury.
Commercial Laminin α-4 antibodies are typically raised in hosts like rabbits or mice, available as monoclonal or polyclonal forms. Researchers prioritize antibodies with high specificity, often verified via knockout controls. Understanding laminin α-4 dynamics through these antibodies provides insights into basement membrane biology and potential therapeutic targets for diseases involving extracellular matrix dysfunction.
×
