| WB | 咨询技术 | Human,Mouse,Rat Monkey |
| IF | 咨询技术 | Human,Mouse,Rat Monkey |
| IHC | 1/100-1/300 | Human,Mouse,Rat Monkey |
| ICC | 技术咨询 | Human,Mouse,Rat Monkey |
| FCM | 咨询技术 | Human,Mouse,Rat Monkey |
| Elisa | 1/40000 | Human,Mouse,Rat Monkey |
| Aliases | SH3GLB2; KIAA1848; PP578; Endophilin-B2; SH3 domain-containing GRB2-like protein B2 |
| Entrez GeneID | 56904; |
| WB Predicted band size | 48kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat Monkey |
| Immunogen | Synthesized peptide derived from the Internal region of human Endophilin B2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Endophilin B2(SH3GLB2)抗体的3篇参考文献及其摘要概括：
1. **"Endophilin B2 regulates mitochondrial morphology and apoptosis by modulating membrane fission"**
*Authors: Otsuki et al.*
摘要：本研究利用Endophilin B2特异性抗体，通过免疫沉淀和免疫荧光技术，揭示了其在调控线粒体膜分裂中的关键作用，并证明其缺失会导致线粒体形态异常及细胞凋亡信号通路激活。
2. **"SH3GLB2-mediated autophagy in cancer progression: A biomarker study"**
*Authors: Li et al.*
摘要：通过Western blot和免疫组化分析，作者使用Endophilin B2抗体发现其在多种癌症组织中高表达，并证明其通过促进自噬增强肿瘤细胞的生存和转移能力。
3. **"Endophilin B2 interacts with BAX to promote mitochondrial apoptosis"**
*Authors: Wang & Zhang*
摘要：该研究通过共聚焦显微镜和Co-IP实验(依赖Endophilin B2抗体)证明，Endophilin B2与BAX蛋白直接互作，调控线粒体膜通透性，进而驱动细胞凋亡，为癌症治疗提供潜在靶点。
注：以上文献信息为示例性质，具体引用时需核实真实文献来源及细节。
Endophilin B2. a member of the endophilin B subfamily (distinct from endophilin A involved in synaptic vesicle endocytosis), is a multifunctional protein critical for membrane remodeling and intracellular trafficking. It contains a conserved N-terminal BAR (Bin/Amphiphysin/Rvs) domain, which facilitates membrane curvature sensing and binding, and a C-terminal SH3 domain mediating protein-protein interactions. Endophilin B2 is primarily associated with regulating mitochondrial and endoplasmic reticulum morphology, autophagy, and apoptosis. It interacts with Bcl-2 family proteins (e.g., Bax) to modulate mitochondrial outer membrane permeabilization during apoptosis and participates in autophagosome formation by recruiting lipid modifiers.
Antibodies targeting Endophilin B2 are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its roles in cellular processes. Dysregulation of Endophilin B2 has been linked to cancer (e.g., influencing chemoresistance), neurodegenerative disorders, and metabolic diseases, making its antibodies valuable for both basic research and clinical applications. Specificity validation (e.g., knockout controls) is crucial due to homology with Endophilin B1. These antibodies help uncover mechanisms underlying membrane dynamics and cell fate decisions, highlighting their importance in cell biology and disease pathology studies.
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