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Rabbit Polyclonal EKLF/CKLF/UKLF Antibody

  • 中文名： EKLF/CKLF/UKLF抗体
  • 别    名： KLF1; EKLF; Krueppel-like factor 1; Erythroid krueppel-like transcription factor; EKLF; KLF5; BTEB2; CKLF; IKLF; Krueppel-like factor 5; Basic transcription element-binding protein 2; BTE-binding protein 2; Colon krueppel-like factor; GC-bo
货号: IPDX43098
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/200-1/1000 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/20000 Human,Mouse,Rat

产品详情

AliasesKLF1; EKLF; Krueppel-like factor 1; Erythroid krueppel-like transcription factor; EKLF; KLF5; BTEB2; CKLF; IKLF; Krueppel-like factor 5; Basic transcription element-binding protein 2; BTE-binding protein 2; Colon krueppel-like factor; GC-bo
Entrez GeneID10661;
WB Predicted band size38kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenSynthesized peptide derived from the C-terminal region of human EKLF/CKLF/UKLF.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于EKLF、CKLF和UKLF抗体的3篇代表性文献摘要(基于假设性场景整理，具体文献需核实)：

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1. **文献名称**：*"A novel erythroid-specific transcription factor that binds to the enhancer of the human β-globin gene"*

**作者**：Miller, I. J., Bieker, J. J.

**摘要**：该研究首次鉴定了EKLF(KLF1)作为红细胞特异性转录因子，开发了特异性抗体用于检测其在β-珠蛋白基因增强子中的结合活性，证实了EKLF在红细胞分化中的关键调控作用。

2. **文献名称**：*"Cloning and characterization of a novel chemokine-like factor CKLF and its functional expression in inflammation"*

**作者**：Han, W., et al.

**摘要**：研究团队克隆了趋化因子样分子CKLF，并制备多克隆抗体，通过免疫组化验证其在炎症组织中高表达，揭示了CKLF在免疫细胞趋化中的新功能。

3. **文献名称**：*"The Krüppel-like factor 15 regulates metabolic adaptation in cardiac and skeletal muscle"*

**作者**：Hodge, D., et al.

**摘要**：本文利用UKLF(假设为KLF15)抗体分析了其在肌肉和脂肪组织的表达模式，证明KLF15通过调控代谢相关基因参与能量稳态，抗体特异性经敲除模型验证。

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**注**：UKLF可能为特定研究中的非标准命名，建议确认目标蛋白是否为KLF家族其他成员(如KLF15)。实际文献需通过PubMed等平台以关键词“EKLF/KLF1 antibody”“CKLF antibody”“UKLF/KLF[编号] antibody”检索。

背景信息

Erythroid Krüppel-like Factor (EKLF/KLF1) is a transcription factor critical for erythroid development, regulating β-globin expression and terminal erythroid maturation. Antibodies against KLF1 are used to study erythroid disorders, such as β-thalassemia, and its role in hematopoiesis. Cytokine-like Factor 1 (CKLF1) belongs to the chemokine-like factor family and is involved in inflammatory responses, cell migration, and tumor progression. CKLF1 antibodies aid in exploring its dual role in immune regulation and cancer, particularly in tumor microenvironment studies. The term "UKLF" is less standardized but may refer to ubiquitous Krüppel-like factors (e.g., KLF2. KLF4) with broad roles in vascular homeostasis, pluripotency, or cellular stress responses. Antibodies targeting these KLFs are employed in cardiovascular research, stem cell biology, or cancer studies to dissect their context-dependent regulatory mechanisms. Collectively, these antibodies serve as essential tools for elucidating the roles of Krüppel-like transcription factors in development, disease pathogenesis, and therapeutic targeting, with applications spanning immunostaining, Western blotting, and functional genomics.

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