| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ELF4; ELFR; MEF; ETS-related transcription factor Elf-4; E74-like factor 4; Myeloid Elf-1-like factor |
| Entrez GeneID | 2000; |
| WB Predicted band size | 70kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the Internal region of human Elf-4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇涉及ELF4(E74样因子4)抗体的参考文献示例(注：文献为模拟概括，实际引用请核实原文)：
1. **"ELF4 regulates antiviral immunity through transcriptional control of interferon-stimulated genes"**
*作者：Li X. et al.*
摘要：研究利用ELF4特异性抗体进行ChIP-seq分析，揭示ELF4直接结合干扰素刺激基因启动子，调控抗病毒免疫反应机制。
2. **"The role of ELF4 in DNA damage response and hematopoiesis"**
*作者：Miyazaki M. et al.*
摘要：通过ELF4抗体进行免疫荧光和Western blot，证实ELF4通过ATM/ATR通路参与DNA损伤修复，并影响造血干细胞稳态。
3. **"ELF4 promotes tumor angiogenesis via VEGF signaling in colorectal cancer"**
*作者：Wang Y. et al.*
摘要：使用ELF4抗体进行免疫组化分析临床样本，发现ELF4高表达与VEGF信号激活相关，促进结直肠癌血管生成及转移。
注：若需真实文献，建议在PubMed中检索关键词 "ELF4 antibody" 或结合具体研究领域筛选(如癌症、免疫方向)。部分研究可能侧重ELF4功能而非抗体开发，建议进一步阅读全文确认实验方法。
**Background of Elf-4 Antibody**
The Elf-4 antibody targets the E74-like factor 4 (ELF4), a transcription factor belonging to the ETS family, which plays a critical role in immune regulation and cellular processes. ELF4 is primarily expressed in immune cells, including T cells and natural killer (NK) cells, where it modulates the expression of genes involved in inflammation, apoptosis, and immune responses. It is known to regulate the production of interferon-gamma (IFN-γ) and other cytokines, linking it to antiviral and antitumor activities.
Elf-4 antibodies are essential tools in research for detecting ELF4 expression in experimental models, aiding in studies on immune system function, cancer biology, and autoimmune diseases. For instance, ELF4 has been implicated in leukemogenesis, with its dysregulation observed in certain hematologic malignancies. Antibodies against ELF4 enable visualization and quantification of this protein via techniques like Western blotting, immunohistochemistry, and flow cytometry.
The development of Elf-4 antibodies has also advanced therapeutic exploration, particularly in targeting pathways where ELF4 interacts with molecules like STING (stimulator of interferon genes) to influence innate immunity. Understanding ELF4's dual roles—both as a tumor suppressor and promoter in different contexts—highlights the importance of specific antibodies in deciphering its complex mechanisms. Current research continues to explore its potential as a biomarker or therapeutic target in diseases ranging from cancer to chronic inflammatory conditions.
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