| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | BMP5; Bone morphogenetic protein 5; BMP-5 |
| Entrez GeneID | 653; |
| WB Predicted band size | 52kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the Internal region of human BMP-5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是模拟生成的关于BMP-5抗体的参考文献示例(注：实际文献需通过学术数据库核实)：
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1. **"Monoclonal Antibody-Based Detection of BMP-5 in Skeletal Development"**
*Author: Smith J, et al.*
摘要：本研究开发了一种特异性识别BMP-5的单克隆抗体，通过免疫组化分析揭示了BMP-5在小鼠胚胎骨骼形成中的时空表达模式，支持其在软骨内成骨中的调控作用。
2. **"BMP-5 Antibody Application in Tissue Regeneration Studies"**
*Author: Tanaka R, et al.*
摘要：利用多克隆抗体阻断BMP-5信号通路，证明其在肌肉损伤修复中促进成纤维细胞向肌细胞分化的关键功能，为再生医学提供新靶点。
3. **"A Novel BMP-5 ELISA Kit with High Specificity: Validation in Clinical Samples"**
*Author: Chen L, et al.*
摘要：报道了一种基于新型兔源多克隆抗体的BMP-5定量检测方法，验证了其在骨关节炎患者血清中的灵敏度与临床相关性，优于传统检测技术。
4. **"BMP-5 Neutralizing Antibody Attenuates Fibrosis in Pulmonary Disease Models"**
*Author: García M, et al.*
摘要：通过中和抗体抑制BMP-5活性，显著减轻小鼠肺纤维化病理进展，提示BMP-5可能成为肺部纤维化治疗的干预靶点。
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建议通过 **PubMed/Google Scholar** 检索真实文献，关键词组合如：
`BMP-5 antibody + detection/therapy/development`，或筛选涉及 **BMP信号通路、骨骼疾病、抗体开发** 等领域的研究。
**Background of BMP-5 Antibody**
Bone Morphogenetic Protein 5 (BMP-5), a member of the TGF-β superfamily, plays critical roles in embryonic development, tissue homeostasis, and cellular differentiation. It regulates processes like skeletal formation, organogenesis, and wound healing by signaling through SMAD-dependent pathways. BMP-5 antibodies are essential tools for studying its expression, localization, and function in both normal and pathological conditions.
These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect BMP-5 in various biological samples. Research has linked BMP-5 dysregulation to diseases including fibrosis, cancer, and skeletal disorders, making its antibody valuable for mechanistic studies and biomarker discovery. For example, elevated BMP-5 levels are observed in certain tumors, suggesting potential roles in tumor progression or suppression.
BMP-5 antibodies also aid in exploring therapeutic applications. By neutralizing BMP-5 activity, researchers investigate its contribution to pathways involved in bone regeneration or pathological calcification. Additionally, animal models with BMP-5 mutations (e.g., short ear mice) highlight its importance in developmental biology, further driving antibody-based research. Available as monoclonal or polyclonal forms, BMP-5 antibodies enable precise targeting, supporting advancements in regenerative medicine and drug development. Their utility spans basic research, diagnostics, and translational studies, underscoring their significance in biomedical science.
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