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Rabbit Polyclonal ABCC1 Antibody

  • 中文名: ABCC1抗体
  • 别    名: MRP7; SIMRP7; EST182763
货号: IPDX42881
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/50 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMRP7; SIMRP7; EST182763
Entrez GeneID89845;
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide corresponding to a region derived from internal residues of human ATP-binding cassette, sub-family C (CFTR/MRP), member 10
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ABCC1(MRP1)抗体的3篇代表性文献,涵盖功能研究、抗体验证及临床关联分析:

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1. **标题**: "Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP1 (ABCC1)"

**作者**: Deeley, R.G., et al.

**摘要**: 综述了ABCC1的转运机制及其在肿瘤多药耐药中的作用,重点讨论了抗体在蛋白定位及表达水平检测中的应用,为耐药性研究提供工具支持。

2. **标题**: "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line"

**作者**: Cole, S.P., et al.

**摘要**: 首次克隆ABCC1基因并建立耐药细胞模型,通过特异性抗体验证其蛋白过表达,证实ABCC1与化疗药物外排及耐药表型直接相关。

3. **标题**: "Characterization of monoclonal antibodies for the detection of multidrug resistance-associated protein (MRP1)"

**作者**: Flens, M.J., et al.

**摘要**: 系统评估了多种抗MRP1单克隆抗体的特异性,验证其在Western blot、免疫组化及流式细胞术中的适用性,为实验选择可靠抗体提供依据。

4. **标题**: "Increased expression of the multidrug resistance protein 1 (MRP1) in relapsed acute myeloid leukemia"

**作者**: Nørgaard, J.M., et al.

**摘要**: 利用抗MRP1抗体检测白血病患者骨髓样本,发现复发患者中ABCC1表达显著升高,提示其作为预后标志物的潜在价值。

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这些文献涵盖了基础机制、抗体开发及临床研究,可为ABCC1抗体应用提供多角度参考。如需具体期刊信息或发表年份,可进一步补充数据库检索。

背景信息

The ABCC1 antibody is a crucial tool for studying the ATP-binding cassette subfamily C member 1 (ABCC1), also known as multidrug resistance-associated protein 1 (MRP1). ABCC1 is a membrane-bound transporter protein involved in the efflux of various endogenous and exogenous compounds, including glutathione-conjugated metabolites, antiviral drugs, and chemotherapeutic agents. Its overexpression in cancer cells is linked to multidrug resistance (MDR), a major challenge in oncology. ABCC1 antibodies are designed to detect and quantify ABCC1 expression in tissues or cells, aiding research on drug resistance mechanisms, cellular detoxification pathways, and pharmacokinetics. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry. Specificity and validation (e.g., using knockout cell lines) are critical, as ABCC1 shares structural homology with other ABC transporters. Research applications span oncology, neurobiology (due to ABCC1's role in blood-brain barrier function), and inflammatory diseases. Understanding ABCC1's regulation and interaction with therapeutics remains a key focus, with implications for developing strategies to overcome MDR or modulate drug distribution in targeted tissues.

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