Rabbit Polyclonal GRIN1 Antibody

The GRIN1 antibody is a crucial tool in neuroscience research, targeting the GluN1 subunit encoded by the GRIN1 gene, which is an essential component of N-methyl-D-aspartate (NMDA) receptors. These ligand-gated ion channels play a central role in synaptic plasticity, learning, and memory by mediating calcium influx upon glutamate binding. The GluN1 subunit is obligatory for NMDA receptor assembly and function, forming heterotetrameric complexes with GluN2 or GluN3 subunits. GRIN1 antibodies are widely used to study receptor expression, localization, and post-translational modifications in brain tissues or cell models. Dysregulation of NMDA receptors, particularly those containing GluN1. has been implicated in neurological and psychiatric disorders, including Alzheimer’s disease, epilepsy, schizophrenia, and ischemic brain injury. Researchers employ GRIN1 antibodies in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate receptor alterations in disease models or genetic manipulations. Specificity validation via knockout controls is critical, as splice variants and phosphorylation states of GluN1 may influence antibody recognition. These reagents also aid in exploring the therapeutic potential of NMDA receptor modulation while considering the delicate balance between receptor hypofunction and excitotoxicity.