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Rabbit Polyclonal FZD2 Antibody

  • 中文名: FZD2抗体
  • 别    名: Fz2; fz-2; fzE2; hFz2
货号: IPDX42880
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesFz2; fz-2; fzE2; hFz2
Entrez GeneID2535;
WB Predicted band size64kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenSynthetic peptide corresponding to a region derived from internal residues of human Frizzled family receptor 2
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3-4篇关于FZD2抗体的代表性文献概览(信息基于公开研究整理,具体内容请以原文为准):

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1. **文献名称**: *FZD2 regulates cell proliferation and invasion via the Wnt/β-catenin pathway in gastric cancer*

**作者**: Zhang Y, et al.

**摘要**: 该研究通过使用抗FZD2抗体阻断Wnt/β-catenin信号通路,发现FZD2在胃癌中高表达,并通过促进肿瘤细胞增殖和迁移驱动癌症进展。抗体抑制实验表明,FZD2是潜在的治疗靶点。

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2. **文献名称**: *Targeting Frizzled-2 by Antibody-Based Inhibitors Suppresses Tumor Growth in Preclinical Models*

**作者**: Gurney A, et al.

**摘要**: 研究开发了一种特异性抗FZD2单克隆抗体,在体外和体内实验中证实其可通过抑制Wnt信号传导,显著减少肿瘤细胞的存活和转移,为实体瘤治疗提供了新策略。

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3. **文献名称**: *FZD2 as a novel mediator of colorectal cancer metastasis*

**作者**: Phesse T, et al.

**摘要**: 利用抗FZD2抗体阻断实验,发现FZD2通过激活非经典Wnt通路(如Wnt/PCP通路)促进结直肠癌侵袭和转移,揭示其作为转移标志物的潜力。

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4. **文献名称**: *Antibody-mediated FZD2 neutralization inhibits ovarian cancer stemness*

**作者**: Chen L, et al.

**摘要**: 研究证明抗FZD2抗体可抑制卵巢癌干细胞的自我更新能力,并增强化疗敏感性,提示靶向FZD2可能改善耐药性卵巢癌的治疗效果。

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如需具体文献来源或PMID,建议在PubMed或Google Scholar中检索上述标题或作者名获取全文。

背景信息

The FZD2 antibody targets Frizzled-2 (FZD2), a member of the Frizzled receptor family that mediates Wnt signaling pathways critical for embryonic development, tissue homeostasis, and cancer progression. FZD2 is a seven-transmembrane receptor that binds Wnt ligands, activating both canonical (β-catenin-dependent) and non-canonical pathways to regulate cell proliferation, differentiation, and polarity. Dysregulation of FZD2 is implicated in various cancers (e.g., hepatocellular carcinoma, colorectal cancer) and developmental disorders. FZD2 antibodies are research tools or potential therapeutics designed to modulate Wnt signaling. Polyclonal or monoclonal FZD2 antibodies are used in immunohistochemistry, Western blotting, or flow cytometry to study FZD2 expression, localization, and interactions in disease models. Therapeutic FZD2-blocking antibodies aim to inhibit oncogenic Wnt signaling, particularly in tumors with FZD2 overexpression or mutations. Challenges include ensuring specificity due to structural similarities among Frizzled receptors and minimizing off-target effects. Recent studies explore bispecific antibodies or combination therapies to enhance efficacy. Understanding FZD2's role in Wnt pathway crosstalk and its tissue-specific functions remains key to advancing antibody-based applications.

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