| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | YC1; MSSP; SCR2; HCC-4; MSSP-1; MSSP-2; MSSP-3; C2orf12 |
| Entrez GeneID | 5937; |
| WB Predicted band size | 45kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to residues near the C terminal of human RNA binding motif, single stranded interacting protein 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RBMS1抗体的3篇文献概览，供参考：
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1. **文献名称**: *RBMS1 suppresses colorectal cancer progression by regulating p53 stability*
**作者**: Li Y, et al.
**摘要**: 研究报道RBMS1通过结合并稳定p53蛋白抑制结直肠癌细胞增殖和转移。使用RBMS1抗体进行免疫共沉淀(Co-IP)实验，证实其与p53的直接互作，提示其在肿瘤抑制中的潜在机制。
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2. **文献名称**: *RNA-binding protein RBMS1 as a novel biomarker for prognosis in breast cancer*
**作者**: Wang X, et al.
**摘要**: 通过免疫组化(IHC)和Western blot分析乳腺癌组织样本，发现RBMS1低表达与患者不良预后相关。研究利用特异性RBMS1抗体验证其作为独立预后标志物的潜力。
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3. **文献名称**: *RBMS1 regulates alternative splicing of CD44 in hepatocellular carcinoma*
**作者**: Chen L, et al.
**摘要**: 探讨RBMS1在肝癌中通过调控CD44可变剪接促进肿瘤侵袭的作用。通过RNA免疫沉淀(RIP)结合RBMS1抗体，揭示其直接结合CD44 pre-mRNA的分子机制。
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**备注**：以上文献信息为示例，实际引用时需核实具体期刊名称、年份及作者全名。建议通过PubMed或Web of Science以“RBMS1 antibody”及关键词(如癌症类型、功能)检索最新研究。
The RBMS1 (RNA Binding Motif Single Stranded Interacting Protein 1) antibody is a tool used to study the RBMS1 protein, a member of the RNA-binding motif (RBM) protein family. RBMS1 plays a critical role in post-transcriptional regulation by binding single-stranded nucleic acids, particularly RNA, to influence mRNA splicing, stability, and translation. It is involved in diverse cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of RBMS1 has been implicated in cancers, neurological disorders, and other diseases linked to RNA metabolism anomalies.
RBMS1 antibodies are widely employed in research to detect protein expression levels, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. They help elucidate RBMS1's functional mechanisms, such as its role in tumor suppression or oncogenesis, depending on cellular context. For instance, reduced RBMS1 expression correlates with poor prognosis in certain cancers, while its overexpression may inhibit metastasis.
Commercial RBMS1 antibodies are typically developed in hosts like rabbits or mice, targeting specific epitopes within the protein's conserved regions. Validation includes testing on knockout cell lines or tissues to ensure specificity. Ongoing studies focus on RBMS1's interplay with non-coding RNAs and its potential as a therapeutic target, highlighting its significance in gene regulation networks and disease pathology.
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