Rabbit Polyclonal TBX18 Antibody

The TBX18 antibody is a crucial tool for studying the T-box transcription factor 18 (TBX18), a member of the evolutionarily conserved T-box gene family involved in embryonic development. TBX18 plays key roles in regulating tissue-specific gene expression during organogenesis, particularly in the development of the heart, kidneys, and specialized cardiac conduction system cells, such as the sinoatrial node. Researchers employ TBX18 antibodies primarily in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect TBX18 protein expression, localization, and dynamics in tissues or cultured cells. These antibodies are often raised in rabbits or mice using immunogenic peptide sequences derived from conserved regions of the TBX18 protein. Studies leveraging TBX18 antibodies have elucidated its role in cardiac pacemaker cell differentiation, renal stroma formation, and tissue regeneration. Notably, TBX18 has been explored for its potential in reprogramming cardiac fibroblasts into pacemaker-like cells, offering therapeutic insights for arrhythmias. The antibody's specificity is validated through knockout controls or siRNA-based silencing to confirm signal absence in TBX18-deficient samples. Its applications extend to developmental biology research, congenital defect studies, and regenerative medicine, making it a vital reagent for understanding T-box protein functions in health and disease.