Rabbit Polyclonal SDC2 Antibody

Syndecan-2 (SDC2), a member of the syndecan family of transmembrane heparan sulfate proteoglycans, plays critical roles in cell-matrix interactions, cell adhesion, migration, and intracellular signaling. It consists of an extracellular domain modified with glycosaminoglycan chains, a single transmembrane domain, and a cytoplasmic tail that interacts with cytoskeletal and signaling molecules. SDC2 is broadly expressed in various tissues, including endothelial cells, fibroblasts, and certain epithelial cells, and is involved in regulating processes such as angiogenesis, wound healing, and immune responses. Dysregulation of SDC2 has been implicated in pathological conditions, particularly cancer, where it may act as either a tumor suppressor or promoter depending on context. For example, SDC2 downregulation is linked to colorectal cancer progression, while its overexpression correlates with poor prognosis in breast and lung cancers. SDC2 antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques like immunohistochemistry, flow cytometry, and Western blotting to explore SDC2's role in disease mechanisms, tissue development, and potential therapeutic targeting. Recent research also investigates SDC2's interaction with extracellular matrix components and growth factors (e.g., FGF2. VEGF), highlighting its importance in cellular communication pathways.