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Rabbit Polyclonal SVOP Antibody

  • 中文名: SVOP抗体
  • 别    名: Synaptic vesicle 2-related protein; SV2-related protein;
货号: IPDX42624
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSynaptic vesicle 2-related protein; SV2-related protein;
Entrez GeneID55530;
WB Predicted band size61kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from internal of human SVOP.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于SVOP抗体的3篇参考文献示例,基于神经科学领域常见研究方向整理:

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1. **文献名称**: *"Differential Localization of SVOP in Rat Retinal Neurons"*

**作者**: Yamagata, A., et al.

**摘要**: 该研究利用SVOP特异性抗体进行免疫组织化学分析,揭示了SVOP蛋白在大鼠视网膜不同神经元亚型中的差异性定位,提示其可能参与突触囊泡的亚细胞运输调控。

2. **文献名称**: *"SVOP Antibody Validation for Synaptic Protein Profiling in Mouse Brain"*

**作者**: Contreras, B. J., & Smith, T. D.

**摘要**: 文章系统验证了SVOP抗体在小鼠脑组织Western blot和免疫荧光中的特异性,证实SVOP在海马和皮层突触前终末高表达,支持其在囊泡释放中的潜在功能。

3. **文献名称**: *"SVOP Knockdown Alters Neurotransmitter Release Dynamics: Evidence from Antibody-based Silencing"*

**作者**: Patel, D. K., et al.

**摘要**: 通过SVOP抗体介导的功能性沉默实验,研究发现SVOP缺失会显著影响培养神经元中谷氨酸的释放速率,表明其在调控突触传递效率中起关键作用。

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*注:上述文献为示例性质,实际引用时请核实具体文献来源及内容准确性。若需真实文献,建议通过PubMed或Google Scholar以“SVOP antibody”、“synaptic vesicle SVOP”等关键词检索近年研究。*

背景信息

SVOP (Synaptic Vesicle 2-Related Protein) is a transmembrane glycoprotein primarily localized to synaptic vesicles and secretory granules in neurons and neuroendocrine cells. It belongs to the SV2 protein family, which shares structural homology with major facilitator superfamily (MFS) transporters, featuring 12 transmembrane domains and glycosylation sites. Discovered in the late 1990s, SVOP is implicated in regulating synaptic vesicle exocytosis, neurotransmitter release, and vesicle trafficking, though its precise molecular mechanisms remain less defined compared to its homolog SV2A.

SVOP is enriched in brain regions like the hippocampus, cerebellum, and cerebral cortex, suggesting roles in synaptic plasticity and neural circuit function. Studies link it to modulating calcium sensitivity during vesicle fusion and maintaining vesicle pools. Its antibodies, developed for research applications (e.g., Western blotting, immunofluorescence), are critical tools for visualizing SVOP distribution and investigating its functional interplay with other synaptic proteins.

Emerging evidence associates SVOP dysregulation with neurological disorders, including epilepsy and neurodegenerative diseases, though causal relationships require further validation. SVOP antibodies also aid in exploring its potential as a biomarker or therapeutic target. Ongoing research aims to unravel SVOP's contributions to synaptic transmission and pathology, bridging gaps in understanding vesicle dynamics and neuropsychiatric conditions.

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