Rabbit Polyclonal SYT11 Antibody

The SYT11 antibody targets synaptotagmin-11 (SYT11), a member of the synaptotagmin family of vesicular transport proteins. Primarily expressed in the brain, SYT11 is implicated in regulating synaptic vesicle trafficking, neurotransmitter release, and membrane repair. Unlike other synaptotagmins, SYT11 lacks calcium-binding domains, suggesting distinct regulatory mechanisms. It has garnered attention in neurodegenerative research, particularly Parkinson’s disease (PD), as SYT11 mutations or dysregulation are linked to PD pathogenesis. Studies associate SYT11 with LRRK2. a kinase frequently mutated in familial PD, highlighting its role in lysosomal dysfunction and α-synuclein aggregation. SYT11 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to study its expression, localization, and interaction partners in neuronal and non-neuronal tissues. Commercial SYT11 antibodies are typically validated for specificity against recombinant or endogenous proteins, though batch variability may require careful optimization. Research applications extend to exploring SYT11's involvement in cancer, immune responses, and metabolic disorders, reflecting its multifaceted cellular roles. As a tool, SYT11 antibodies help unravel mechanisms underlying synaptic dysfunction and neurodegenerative pathways, offering potential therapeutic insights.