| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; PP2A subunit B isoform B55-beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A subunit B isoform beta |
| Entrez GeneID | 5521; |
| WB Predicted band size | 51kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human PPP2R2B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及PPP2R2B相关研究的文献示例(注：文献为虚拟示例，实际引用需核实)：
1. **标题**: *PPP2R2B Suppresses Tumorigenesis in Colorectal Cancer via Modulating Wnt/β-Catenin Signaling*
**作者**: Li X, Wang Y, et al.
**摘要**: 研究通过免疫组化(使用PPP2R2B抗体)发现PPP2R2B在结直肠癌中低表达，其缺失通过激活Wnt通路促进肿瘤生长，提示其作为抑癌基因的潜在作用。
2. **标题**: *PPP2R2B Mutation Causes Spinocerebellar Ataxia Type 12: Functional Analysis via CRISPR-Cas9 Models*
**作者**: Smith JL, Brown KR, et al.
**摘要**: 利用基因编辑和Western blot(依赖PPP2R2B抗体)验证PPP2R2B CAG重复扩增突变导致神经细胞PP2A复合体功能异常，与小脑共济失调发生相关。
3. **标题**: *Proteomic Profiling Reveals PPP2R2B as a Biomarker for Breast Cancer Metastasis*
**作者**: Chen H, Zhang Q, et al.
**摘要**: 通过质谱和免疫沉淀(使用PPP2R2B特异性抗体)发现PPP2R2B表达水平与乳腺癌转移负相关，机制涉及调控细胞迁移相关激酶信号。
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**提示**：实际研究中建议通过PubMed或Web of Science检索真实文献(关键词如“PPP2R2B antibody”、“PPP2R2B cancer/neurological disease”)。若需具体文献，可提供更详细的研究方向(如疾病类型或分子机制)。
The PPP2R2B antibody targets the protein encoded by the PPP2R2B gene, which is a regulatory subunit (B55β) of protein phosphatase 2A (PP2A), a critical serine/threonine phosphatase involved in diverse cellular processes. PP2A regulates signal transduction pathways by counterbalancing kinase activities, impacting cell cycle progression, apoptosis, DNA damage response, and metabolism. The PPP2R2B subunit directs PP2A’s substrate specificity and cellular localization, modulating its activity toward distinct targets.
PPP2R2B is notably linked to neurological disorders. Expanded CAG repeats in the PPP2R2B gene cause spinocerebellar ataxia type 12 (SCA12), a rare autosomal dominant neurodegenerative disease characterized by tremors, gait ataxia, and cognitive decline. The mutation is thought to induce toxic RNA aggregates or alter PP2A function, disrupting neuronal signaling.
Antibodies against PPP2R2B are essential tools in research to study its expression, localization, and interaction partners. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate PPP2R2B’s role in PP2A complex assembly, its tissue-specific distribution (e.g., high neuronal expression), and dysregulation in disease contexts. Such studies aim to clarify PPP2R2B’s contribution to neurodegeneration and potential therapeutic targets. Commercial PPP2R2B antibodies vary in specificity, requiring validation to ensure recognition of the correct isoform and avoid cross-reactivity.
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