| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine protease inhibitor Kazal-type 6; SPINK6; |
| Entrez GeneID | 404203; |
| WB Predicted band size | 9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human SPINK6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及SPINK6抗体的参考文献概览：
1. **文献名称**：*SPINK6 is a murine body epidermal protease inhibitor*
**作者**：Meyer-Hoffert U, et al.
**摘要**：该研究在小鼠皮肤中发现SPINK6通过抑制组织蛋白酶等蛋白酶维持表皮屏障功能，并利用特异性抗体证实其在角质形成细胞中的定位及表达调控机制。
2. **文献名称**：*SPINK6 inhibits proteases involved in skin desquamation*
**作者**：Sales KU, et al.
**摘要**：文章通过免疫组化和Western blot技术，使用抗SPINK6抗体揭示其在人皮肤外层中抑制KLK5和KLK14的活性，从而调控角质层脱落过程的分子机制。
3. **文献名称**：*Protease inhibitor SPINK6 promotes epithelial barrier formation*
**作者**：Wu Z, et al.
**摘要**：研究通过抗SPINK6抗体阻断实验，证明SPINK6在皮肤创面愈合中通过抑制过度蛋白酶活性促进上皮屏障重建，为治疗皮肤损伤提供新靶点。
*注：若需具体文献年份或期刊，建议通过PubMed/Google Scholar以标题及作者检索获取全文细节。*
**Background of SPINK6 Antibody**
SPINK6. a member of the serine protease inhibitor Kazal-type (SPINK) family, is a secreted protein primarily expressed in epithelial tissues, including the skin and mucosal surfaces. It functions as a potent inhibitor of specific serine proteases, particularly kallikrein-related peptidases (KLKs), which are involved in skin barrier maintenance, desquamation, and inflammatory signaling. SPINK6 plays a critical role in regulating proteolytic activity to prevent excessive tissue damage and maintain epidermal homeostasis.
Research highlights its importance in skin diseases such as atopic dermatitis and Netherton syndrome, where dysregulated protease activity contributes to pathological inflammation and barrier dysfunction. SPINK6 is also implicated in mucosal immunity, with studies suggesting antimicrobial and wound-healing properties in oral and genital epithelia.
Antibodies targeting SPINK6 are essential tools for detecting its expression, localization, and interaction partners in both physiological and disease contexts. They enable applications like immunohistochemistry, Western blotting, and ELISA to explore SPINK6's tissue-specific roles, regulatory mechanisms, and potential therapeutic relevance. Recent studies further utilize SPINK6 antibodies to investigate its diagnostic or prognostic value in epithelial disorders and chronic inflammatory conditions.
Overall, SPINK6 antibodies serve as vital reagents for advancing understanding of protease-mediated pathways in epithelial biology and disease.
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