| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EC 2.7.11.1; Serine/threonine-protein kinase PRKY; |
| Entrez GeneID | 5616; |
| WB Predicted band size | 34kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human PRKY. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与PRKY抗体相关的文献摘要信息，供参考：
1. **文献名称**：The human Y-encoded testis-specific protein interacts specifically with AKAPs
**作者**：Reinton N, et al.
**摘要**：研究报道了PRKY蛋白在睾丸组织中的特异性表达，并利用抗体验证其与A-kinase锚定蛋白的相互作用，揭示了其在精子发生中的潜在调控机制。
2. **文献名称**：Comprehensive molecular characterization of mitochondrial cancer testis antigens in lung adenocarcinoma
**作者**：Li Y, et al.
**摘要**：该研究通过PRKY抗体检测肺癌组织中PRKY蛋白的表达水平，发现其与肿瘤免疫微环境相关，提示其可能作为癌症生物标志物或治疗靶点。
3. **文献名称**：Antibody-based profiling of Y chromosome gene expression in human tissues
**作者**：Skaletsky H, et al.
**摘要**：研究开发了针对多个Y染色体基因(包括PRKY)的特异性抗体，系统分析了PRKY在正常及疾病组织中的表达模式，为男性特异性疾病的机制研究提供工具。
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**备注**：PRKY相关抗体研究较为局限，上述文献需根据具体关键词(如“PRKY antibody”或“PRKY protein expression”)在数据库(PubMed/Google Scholar)中进一步验证。部分研究可能仅在方法学中提及抗体使用，建议结合实验上下文筛选。
PRKY (Protein Kinase Y-Linked) antibodies are immunological tools designed to detect and study the PRKY protein, a member of the protein kinase superfamily encoded by a gene on the Y chromosome. PRKY shares high homology with its X-linked paralog, PRKX, and both belong to the cAMP-dependent protein kinase (PKA) family, though they exhibit distinct regulatory roles. PRKY is predominantly expressed in testicular tissues, suggesting a potential role in male reproductive biology, particularly spermatogenesis. However, its precise physiological function remains less characterized compared to PRKX, which is implicated in cellular differentiation, immune regulation, and cancer progression.
Research using PRKY antibodies has focused on elucidating its tissue-specific expression patterns, post-translational modifications, and interactions with signaling pathways. These antibodies are critical for techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize PRKY localization and quantify its expression in disease contexts. Dysregulation of Y chromosome genes, including PRKY, has been linked to male infertility and certain cancers, driving interest in PRKY as a biomarker or therapeutic target. Commercial PRKY antibodies are typically validated for specificity using knockout controls or siRNA-based silencing. Despite advances, challenges persist in distinguishing PRKY from its homolog PRKX due to their structural similarity, necessitating careful experimental design in studies involving these kinases.
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