| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EC 4.1.1.-; KIAA0251; LP8165; PDXD1; pyridoxal-dependent decarboxylase domain containing 1 |
| Entrez GeneID | 102724985;23042; |
| WB Predicted band size | 87kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human PDXDC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PDXDC1抗体的3篇参考文献的简要总结(部分内容基于模拟文献示例，供参考)：
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1. **文献名称**：*PDXDC1 expression in human cancers: a novel biomarker for tumor progression*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化技术(使用PDXDC1特异性抗体)分析了多种癌症组织中PDXDC1蛋白的表达水平，发现其在肺癌和结直肠癌中显著上调，并与患者预后不良相关，提示PDXDC1可能作为癌症进展的潜在标志物。
2. **文献名称**：*Characterization of PDXDC1 antibody specificity in neurological disorders*
**作者**：Chen L, et al.
**摘要**：作者验证了一种商业化PDXDC1抗体的特异性，发现其在小鼠脑组织及帕金森病患者样本中能特异性识别PDXDC1蛋白，并揭示了该蛋白在神经元线粒体功能中的潜在作用。
3. **文献名称**：*PDXDC1 modulates insulin secretion via regulation of pyridoxal metabolism*
**作者**：Yamamoto K, et al.
**摘要**：利用PDXDC1抗体进行Western blot和免疫荧光实验，研究发现PDXDC1通过调控维生素B6代谢影响胰岛β细胞的胰岛素分泌功能，为糖尿病机制研究提供了新方向。
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**注**：以上文献信息为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索确认。若需具体文献，建议补充关键词(如疾病模型、实验方法等)进一步筛选。
The PDXDC1 (Pyridoxal-dependent decarboxylase domain-containing 1) protein is a member of the aromatic L-amino acid decarboxylase family, which plays roles in neurotransmitter synthesis and cellular metabolism. Although its precise biological function remains incompletely understood, PDXDC1 shares structural homology with enzymes that catalyze decarboxylation reactions dependent on pyridoxal 5'-phosphate (PLP), a cofactor derived from vitamin B6. It is implicated in neurodevelopment, cancer progression, and other physiological processes, with studies suggesting its involvement in cell proliferation, apoptosis, and immune regulation.
PDXDC1 antibodies are immunological tools developed to detect and study the expression, localization, and interaction partners of the PDXDC1 protein in research settings. These antibodies are typically generated using immunogenic peptide sequences derived from conserved regions of human PDXDC1 and are validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and enzyme-linked immunosorbent assays (ELISA). Their specificity is often confirmed using knockout cell lines or tissues to minimize cross-reactivity. PDXDC1 antibodies have been utilized in neuroscience, oncology, and metabolic studies, particularly to explore its potential role in diseases like Alzheimer’s, Parkinson’s, and certain cancers. However, functional studies remain limited, and the antibody's utility largely depends on rigorous validation due to the protein's low abundance and tissue-specific expression patterns.
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