Rabbit Polyclonal FAM35A/B Antibody

FAM35A (Family with sequence similarity 35 member A), also known as RINN1 or C17orf53. and its paralog FAM35B (RINN3) are evolutionarily conserved proteins implicated in DNA damage response and genome stability. FAM35A interacts with RNF168. a key E3 ubiquitin ligase in the DNA repair pathway, facilitating recruitment of repair proteins to double-strand break (DSB) sites. Studies suggest FAM35A acts as a scaffold to stabilize RNF168. ensuring proper ubiquitination signaling for homologous recombination repair. FAM35B shares structural homology but exhibits distinct functional roles, potentially regulating mitotic progression and chromosome segregation. Antibodies targeting FAM35A/B are critical tools for investigating their expression, localization, and molecular interactions. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study their roles in cancer (e.g., breast and ovarian cancers), where DNA repair defects are common. Commercially available FAM35A/B antibodies are typically raised in rabbits or mice, validated for specificity against human isoforms. Recent research highlights FAM35A's potential as a biomarker for therapy response in BRCA-deficient cancers, emphasizing the importance of reliable antibodies in both basic and translational studies.