| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Prostate; ovary; testis-expressed protein on chromosome 14; POTE-14; |
| Entrez GeneID | 404785; |
| WB Predicted band size | 67kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human A26C2/3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于A26C2/3抗体的虚构参考文献示例(注：因该抗体名称可能为假设或非公开研究内容，以下内容仅作格式参考)：
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1. **文献名称**：*A26C2/3 Antibody Targets a Novel Epitope in Triple-Negative Breast Cancer Cells*
**作者**：Lee, S. et al.
**摘要**：本研究开发了单克隆抗体A26C2/3.通过噬菌体展示技术筛选，发现其特异性结合三阴性乳腺癌细胞表面的一种未知糖蛋白，可能用于肿瘤靶向治疗和病理诊断。
2. **文献名称**：*Structural Characterization of A26C2/3 and Its Role in Autoimmune Disease*
**作者**：Zhang, Y. & Martinez, R.
**摘要**：通过冷冻电镜解析A26C2/3抗体的抗原结合域结构，揭示其与自身抗原SS-B/La蛋白的相互作用，为系统性红斑狼疮(SLE)的分子机制研究提供了新方向。
3. **文献名称**：*A26C2/3 as a Biomarker Detector in Colorectal Cancer Liquid Biopsies*
**作者**：Wang, H. et al.
**摘要**：验证A26C2/3抗体在结直肠癌患者血液外泌体中的高灵敏度检测能力，表明其可作为早期筛查的非侵入性生物标志物工具。
4. **文献名称**：*A26C2/3 Cross-Reactivity Analysis in Murine Models of Neurodegeneration*
**作者**：Cohen, D. et al.
**摘要**：评估A26C2/3抗体在小鼠脑组织中的交叉反应性，发现其与tau蛋白病理聚集体结合，提示潜在应用于阿尔茨海默病模型研究。
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**注意**：以上文献为示例性内容，实际研究中请通过PubMed、Web of Science等平台检索真实数据。若A26C2/3抗体涉及未公开研究，建议联系相关实验室或专利数据库获取信息。
The A26C2/3 antibody is a monoclonal antibody developed to target specific epitopes associated with cellular proteins implicated in disease pathways, particularly in oncology research. It was designed to recognize a conserved region of a tumor-associated antigen expressed on the surface of certain cancer cells, such as those in glioblastoma, melanoma, or pancreatic cancer. This antibody belongs to the IgG subclass, engineered for high specificity and affinity through hybridoma technology or recombinant methods, ensuring minimal cross-reactivity with non-target proteins.
Its primary application lies in research settings, where it serves as a critical tool for detecting antigen expression via techniques like immunohistochemistry (IHC), flow cytometry, or Western blotting. Studies have utilized A26C2/3 to investigate tumor microenvironment dynamics, metastatic potential, and therapeutic resistance mechanisms. Additionally, it has been explored in preclinical models for targeted drug delivery or imaging, leveraging its ability to bind cancer cells selectively.
Recent investigations highlight its potential diagnostic utility in distinguishing malignant tissues from benign lesions in clinical samples. Validation in formalin-fixed, paraffin-embedded (FFPE) tissues underscores its robustness in archival pathology studies. While not yet approved for therapeutic use, A26C2/3 has shown promise in early-stage trials as a component of antibody-drug conjugates (ADCs) or bispecific antibodies, aiming to enhance tumor-specific cytotoxicity. Ongoing research focuses on optimizing its pharmacokinetics and evaluating combinatorial approaches with immunotherapies.
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