Rabbit Polyclonal DQX1 Antibody

The DQX1 antibody targets the DQX1 protein, a DEAD-box RNA helicase implicated in diverse cellular processes, including RNA metabolism, ribosome biogenesis, and genome stability. DQX1 contains conserved DEAD-box motifs critical for ATP-dependent RNA unwinding and protein-RNA interactions. Studies suggest its involvement in pre-mRNA splicing, rRNA processing, and resolving R-loops—three-stranded nucleic acid structures linked to transcription-replication conflicts and DNA damage. DQX1 is also essential in germ cell development, particularly during spermatogenesis, where it regulates mRNA translation and chromatin compaction. Dysregulation of DQX1 has been associated with infertility, neurodevelopmental disorders, and cancers such as glioblastoma and germ cell tumors. Antibodies against DQX1 are widely used in research to investigate its expression patterns, subcellular localization (primarily nuclear), and molecular interactions via techniques like immunoprecipitation, Western blotting, and immunofluorescence. Recent work highlights DQX1's potential as a therapeutic target, especially in cancers with aberrant RNA processing or replication stress. However, its precise mechanistic roles in disease contexts remain under active exploration, necessitating further functional studies using validated DQX1-specific antibodies.