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Rabbit Polyclonal DQX1 Antibody

  • 中文名： DQX1抗体
  • 别    名： ATP-dependent RNA helicase DQX1; DEAQ box 1; DEAQ RNA-dependent ATPase DQX1; EC 3.6.1.-;
货号: IPDX42302
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesATP-dependent RNA helicase DQX1; DEAQ box 1; DEAQ RNA-dependent ATPase DQX1; EC 3.6.1.-;
Entrez GeneID165545;
WB Predicted band size79kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenSynthesized peptide derived from internal of human DQX1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于DQX1抗体的3篇参考文献示例(部分信息为模拟，建议通过学术数据库核实)：

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1. **文献名称**: "DQX1 is essential for RNA splicing and cellular viability in mammalian systems"

**作者**: Smith A, et al.

**摘要**: 本研究利用DQX1特异性抗体，通过免疫沉淀和Western blot分析，揭示了DQX1在RNA剪接复合体中的关键作用。抗体验证显示其在多种哺乳动物细胞系中特异性识别DQX1蛋白，并证实其功能缺失导致细胞凋亡。

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2. **文献名称**: "DEAD-box protein DQX1 regulates embryonic stem cell differentiation via mRNA processing"

**作者**: Lee J, et al.

**摘要**: 通过免疫荧光和流式细胞术结合DQX1抗体，研究发现DQX1通过调控多能性相关mRNA的稳定性影响胚胎干细胞分化。抗体特异性验证实验表明其适用于亚细胞定位研究。

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3. **文献名称**: "DQX1 interacts with ATR kinase and modulates DNA damage response pathways"

**作者**: Chen R, et al.

**摘要**: 本研究使用DQX1抗体进行共免疫沉淀实验，发现DQX1与ATR激酶相互作用，参与DNA损伤修复通路。抗体在HeLa细胞模型中验证了DQX1的蛋白表达水平变化与DNA损伤应答的关联。

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**注意**：以上文献信息为示例，建议通过PubMed、Google Scholar或Web of Science检索真实文献，关键词如“DQX1 antibody application”或“DQX1 + immunoprecipitation”。实际文献需核对作者、标题及摘要准确性。

背景信息

The DQX1 antibody targets the DQX1 protein, a DEAD-box RNA helicase implicated in diverse cellular processes, including RNA metabolism, ribosome biogenesis, and genome stability. DQX1 contains conserved DEAD-box motifs critical for ATP-dependent RNA unwinding and protein-RNA interactions. Studies suggest its involvement in pre-mRNA splicing, rRNA processing, and resolving R-loops—three-stranded nucleic acid structures linked to transcription-replication conflicts and DNA damage. DQX1 is also essential in germ cell development, particularly during spermatogenesis, where it regulates mRNA translation and chromatin compaction. Dysregulation of DQX1 has been associated with infertility, neurodevelopmental disorders, and cancers such as glioblastoma and germ cell tumors. Antibodies against DQX1 are widely used in research to investigate its expression patterns, subcellular localization (primarily nuclear), and molecular interactions via techniques like immunoprecipitation, Western blotting, and immunofluorescence. Recent work highlights DQX1's potential as a therapeutic target, especially in cancers with aberrant RNA processing or replication stress. However, its precise mechanistic roles in disease contexts remain under active exploration, necessitating further functional studies using validated DQX1-specific antibodies.

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