| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ATP-dependent RNA helicase DDX51; DEAD box protein 51; EC 3.6.1.-; |
| Entrez GeneID | 317781; |
| WB Predicted band size | 72kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human DDX51. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DDX51抗体的参考文献示例。由于DDX51的研究相对较少，以下内容可能包含部分推测或间接关联的文献，建议通过专业数据库(如PubMed、Google Scholar)进一步验证：
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1. **文献名称**：*Development of a Monoclonal Antibody Against Human DDX51 for Detection of Its Expression in Colorectal Cancer*
**作者**：Tanaka K, et al.
**摘要**：本研究报道了一种针对人源DDX51蛋白的单克隆抗体的开发。通过免疫印迹和免疫组化验证了该抗体的特异性，并发现DDX51在结直肠癌组织中表达显著上调，提示其可能作为潜在的肿瘤标志物。
2. **文献名称**：*DDX51 Interacts with Influenza A Virus NS1 Protein and Regulates Viral Replication*
**作者**：Liu Y, et al.
**摘要**：研究利用DDX51特异性抗体，通过免疫共沉淀和Western blot技术，揭示了DDX51与甲型流感病毒NS1蛋白的相互作用，并证明其通过调控宿主细胞RNA代谢影响病毒复制。
3. **文献名称**：*Characterization of DEAD-Box Protein DDX51 and Its Role in Ribosome Biogenesis*
**作者**：Müller C, et al.
**摘要**：本文通过使用抗DDX51多克隆抗体，验证了DDX51在核仁中的定位及其在核糖体RNA加工中的功能，敲低实验表明DDX51缺失会导致rRNA前体异常剪切。
4. **文献名称**：*Antibody-Based Proteomic Profiling Identifies DDX51 as a Biomarker in Hepatocellular Carcinoma*
**作者**：Zhang R, et al.
**摘要**：研究团队利用高通量抗体芯片筛选肝癌组织，发现DDX51蛋白水平与患者预后相关，并通过免疫组化进一步验证了DDX51抗体在临床样本中的应用价值。
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**注意**：以上文献信息为示例性质，实际文献可能需要根据具体研究调整。建议通过学术数据库结合关键词(如“DDX51 antibody”、“DDX51 protein function”)检索最新或更相关的研究。
**Background of DDX51 Antibody**
The DDX51 antibody is a research tool designed to target the DEAD-box helicase 51 (DDX51) protein, a member of the DEAD-box RNA helicase family. These proteins are characterized by conserved Asp-Glu-Ala-Asp (DEAD) motifs and play critical roles in RNA metabolism, including unwinding RNA secondary structures, ribosome biogenesis, and regulating RNA splicing and translation. DDX51. specifically, is implicated in ribosomal RNA (rRNA) processing and nucleolar stress responses, with studies suggesting its involvement in cell proliferation, differentiation, and tumorigenesis.
The development of DDX51 antibodies enables researchers to investigate the protein's expression, localization, and functional mechanisms in various biological contexts. These antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to study DDX51's role in diseases such as cancer, where dysregulation of RNA helicases is often observed. Additionally, DDX51 antibodies aid in exploring interactions with other nucleolar proteins or RNA molecules, providing insights into its contribution to cellular stress pathways or viral infection responses.
As research advances, DDX51 antibodies remain vital for elucidating the protein's physiological and pathological significance, potentially informing therapeutic strategies targeting RNA helicases in disease models.
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