| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ABC transporter ABCA6; ABCA6; ATP-binding cassette A6; ATP-binding cassette sub-family A member 6; ATP-binding cassette |
| Entrez GeneID | 23460; |
| WB Predicted band size | 185kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human ABCA6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于ABCA6抗体的3篇参考文献(信息基于现有研究概括，非真实文献)：
1. **文献名称**：*ABCA6 Expression and Localization in Human Macrophages: A Role in Lipid Homeostasis*
**作者**：Smith J, et al.
**摘要**：本研究利用特异性ABCA6抗体，通过免疫荧光和Western blot技术，揭示了ABCA6蛋白在巨噬细胞中的表达模式，并发现其可能通过调节胆固醇外流参与脂质代谢调控。
2. **文献名称**：*Characterization of a Novel Monoclonal Antibody Against Human ABCA6*
**作者**：Li X, et al.
**摘要**：报道了一种针对人ABCA6胞外结构域的单克隆抗体的开发与验证，该抗体在免疫组化中显示高特异性，可用于检测肝脏和肾脏组织中ABCA6的蛋白表达水平。
3. **文献名称**：*ABCA6 Genetic Variants and Their Association with Metabolic Syndrome*
**作者**：Garcia R, et al.
**摘要**：通过ABCA6抗体进行蛋白定量分析，结合基因测序数据，探讨了ABCA6基因突变与代谢综合征患者脂质异常的相关性，提示其潜在病理机制。
(注：若需真实文献，建议通过PubMed或Google Scholar以“ABCA6 antibody”为关键词检索近年研究。)
The ABCA6 antibody is a tool used to study the ATP-binding cassette subfamily A member 6 (ABCA6), a protein encoded by the *ABCA6* gene in humans. ABCA6 belongs to the ATP-binding cassette (ABC) transporter superfamily, which facilitates the transport of various molecules across cellular membranes. While ABCA1 and ABCA4 are well-characterized for their roles in lipid metabolism and vision, respectively, ABCA6 remains less understood. It is primarily expressed in the liver, macrophages, and certain cancer cells, suggesting potential roles in lipid homeostasis, cellular detoxification, or disease pathways. Structurally, ABCA6 contains transmembrane domains and nucleotide-binding folds critical for ATP-dependent substrate transport.
Research on ABCA6 antibodies focuses on detecting protein expression, localization, and functional studies. These antibodies (polyclonal or monoclonal) are validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Emerging evidence links ABCA6 dysregulation to metabolic disorders, atherosclerosis, and cancers, though its exact mechanisms remain unclear. Some studies propose ABCA6 may influence cholesterol efflux or drug resistance, but conflicting data highlight the need for further investigation. ABCA6 antibodies thus serve as essential reagents to unravel its biological significance and explore therapeutic targets. Current challenges include clarifying tissue-specific functions, regulatory pathways, and its interaction with lipids or other transporters.
×
