Rabbit Polyclonal DDX3Y Antibody

The DDX3Y antibody is designed to target the DDX3Y protein, a member of the DEAD-box RNA helicase family encoded by the Y-chromosome gene *DDX3Y*. This gene is the male-specific homolog of *DDX3X*, located on the X chromosome, and both proteins play critical roles in RNA metabolism, including splicing, transport, and translation. DDX3Y is particularly important in male development and germ cell regulation, with mutations or deletions linked to male infertility and disorders of sex development. Research has also implicated DDX3Y in various cancers, as its dysregulation or loss is observed in aggressive tumors, particularly those affecting male reproductive tissues. The DDX3Y antibody is widely used in molecular biology and clinical research to study protein expression, localization, and functional interactions in male-specific pathologies. It enables techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore DDX3Y's role in cellular processes, cancer progression, and sex-biased disease mechanisms. Additionally, this antibody aids in distinguishing DDX3Y from its X-linked counterpart, DDX3X, which shares high sequence similarity but may have divergent functions. By facilitating precise detection, the DDX3Y antibody supports investigations into genetic sexual dimorphism, reproductive health, and potential therapeutic targets in oncology.