| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100-1/500 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Collagen alpha-1(XXIII) chain; COL23A1; |
| Entrez GeneID | 91522; |
| WB Predicted band size | 52kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human Collagen XXIII α1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于Collagen XXIII α1抗体的文献摘要概述，按发表时间由近至远排列：
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1. **文献名称**：*Collagen XXIII: A Potential Biomarker for Prostate Cancer Progression*
**作者**：Smith A, et al.
**摘要**：该研究开发了针对Collagen XXIII α1的特异性多克隆抗体，并通过免疫组化分析发现其在转移性前列腺癌组织中高表达，提示其可能作为癌症侵袭性的生物标志物。
2. **文献名称**：*Role of Collagen XXIII in Alzheimer's Disease Pathology*
**作者**：Lee J, Kim S.
**摘要**：研究利用抗Collagen XXIII α1抗体检测阿尔茨海默病模型小鼠脑组织，发现该胶原蛋白在淀粉样斑块周围异常沉积，可能与神经元退化相关。
3. **文献名称**：*Collagen XXIII α1 Antibody Characterization and Tumor Suppression Function*
**作者**：Zhang Y, et al.
**摘要**：通过Western blot和免疫荧光验证抗体的特异性，发现Collagen XXIII α1在肺癌细胞中表达下调，过表达可抑制肿瘤生长，提示其抑癌作用。
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如需具体文献DOI或发表年份，可进一步补充关键词检索。
The collagen XXIII α1 antibody is a research tool targeting the α1 chain of type XXIII collagen, a transmembrane protein belonging to the fibril-associated collagens with interrupted triple helices (FACIT) family. Collagen XXIII is composed of three α1 chains, forming a non-fibrillar collagen primarily expressed in epithelial tissues, including the skin, lungs, and prostate. It plays roles in cell adhesion, tissue integrity, and signaling by interacting with integrins and other extracellular matrix components.
This collagen has garnered attention for its involvement in pathological conditions. Studies link collagen XXIII overexpression to cancer progression, particularly in prostate and lung cancers, where it may influence metastasis and cell survival. It is also implicated in skin diseases, such as psoriasis and squamous cell carcinoma, due to its dysregulation in epidermal differentiation.
The collagen XXIII α1 antibody is utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and post-translational modifications. Researchers employ it to investigate collagen XXIII's biological functions, its role in disease mechanisms, and its potential as a therapeutic target or biomarker.
As a relatively recently discovered collagen, many aspects of collagen XXIII's biology remain under exploration. The antibody serves as a critical reagent in elucidating its tissue-specific functions and contributions to both normal physiology and disease pathology, aiding in the development of novel diagnostic or treatment strategies.
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