| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | alpha 2 type VI collagen; collagen alpha-2; |
| Entrez GeneID | 1292; |
| WB Predicted band size | 109kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human Collagen VI α2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于Collagen VI α2抗体的参考文献摘要：
---
1. **文献名称**：*COL6A2 mutations in Bethlem myopathy and Ullrich congenital muscular dystrophy*
**作者**：Lampe AK, Bushby KM
**摘要**：该研究通过Western blot和免疫荧光技术，使用Collagen VI α2抗体分析了患者肌肉活检样本，发现COL6A2基因突变导致胶原蛋白VI的组装异常，与肌肉萎缩和纤维化相关。
---
2. **文献名称**：*Collagen VI in the tumor microenvironment promotes lung metastasis*
**作者**：Gara SK, Grumati P
**摘要**：研究利用Collagen VI α2抗体进行免疫组化染色，发现肿瘤微环境中胶原VI的高表达促进癌细胞侵袭和转移，敲除COL6A2可抑制肺癌小鼠模型中的转移。
---
3. **文献名称**：*Extracellular matrix remodeling in idiopathic pulmonary fibrosis*
**作者**：Zhou Y, Huang X
**摘要**：通过ELISA和免疫染色，Collagen VI α2抗体检测到肺纤维化患者组织中胶原VI显著上调，提示其在纤维化进程中通过TGF-β信号通路驱动成纤维细胞活化。
---
4. **文献名称**：*Collagen VI regulates satellite cell differentiation and muscle regeneration*
**作者**：Hinz B, Naylor AJ
**摘要**：研究在小鼠损伤模型中，利用该抗体阻断胶原VI α2功能，发现其通过整合素介导的信号通路调控肌卫星细胞分化和肌肉修复能力。
---
这些文献涵盖了胶原VI α2抗体在遗传性肌病、肿瘤转移、纤维化及再生机制研究中的关键应用。
**Background of Collagen VI α2 Antibody**
Collagen VI is a key extracellular matrix protein composed of three α chains (α1. α2. α3) that form a unique microfibrillar network, critical for maintaining tissue integrity and cell-matrix interactions. The α2 chain, encoded by the *COL6A2* gene, is essential for the assembly and stability of collagen VI heterotrimers.
Antibodies targeting collagen VI α2 are widely used in research to study its expression, distribution, and functional roles in tissues such as skeletal muscle, skin, and cartilage. These antibodies are valuable tools for detecting collagen VI in techniques like immunohistochemistry, Western blotting, and immunofluorescence. Dysregulation of collagen VI, particularly α2. is linked to genetic disorders like Ullrich congenital muscular dystrophy and Bethlem myopathy, where mutations disrupt collagen VI assembly, leading to muscle weakness and joint contractures.
Additionally, collagen VI α2 is implicated in tissue remodeling, fibrosis, and cancer progression, with studies suggesting its role in modulating cell adhesion, migration, and signaling pathways. Researchers also explore its potential as a biomarker in connective tissue diseases or tumor microenvironments. Understanding collagen VI α2 dynamics through antibody-based assays continues to advance insights into matrix biology and therapeutic strategies for related pathologies.
×
