| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/100-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Collagen alpha-1(XIV) chain; Undulin; COEA1; |
| Entrez GeneID | 7373; |
| WB Predicted band size | 194kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human Collagen XIV α1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于Collagen XIV α1抗体的关键文献摘要(虚构示例，仅供格式参考)：
1. **文献名称**: "Collagen XIV regulates fibrillogenesis in embryonic connective tissues"
**作者**: Smith A, et al.
**摘要**: 研究利用特异性Collagen XIV α1抗体，发现其在胚胎发育中调控胶原纤维组装，通过免疫组化证实其在肌腱和皮肤中的时空表达模式。
2. **文献名称**: "COL14A1 as a stromal marker in pancreatic cancer progression"
**作者**: Tanaka K, et al.
**摘要**: 通过Western blot和免疫荧光，发现Collagen XIV α1抗体可标记肿瘤相关成纤维细胞(CAFs)，其表达与胰腺癌转移及TGF-β信号通路激活相关。
3. **文献名称**: "Collagen XIV deficiency alters skin biomechanics"
**作者**: Müller SA, et al.
**摘要**: 使用基因敲除小鼠模型结合Collagen XIV α1抗体，证明该蛋白通过调控胶原交联影响皮肤弹性，缺失导致真皮机械性能异常。
(注：以上内容为模拟示例，实际文献需通过PubMed/Google Scholar检索关键词"COL14A1 antibody"或"Collagen XIV alpha 1"获取。)
Collagen XIV α1 (COL14A1) is a component of fibril-associated collagens with interrupted triple helices (FACIT), primarily found in the extracellular matrix (ECM) of connective tissues. It interacts with other collagens, such as types I and III, to regulate fibril organization and tissue integrity. COL14A1 is expressed during specific developmental stages and tissue remodeling, playing roles in cell adhesion, matrix assembly, and mechanical stability. Its expression is often elevated in fibrotic conditions, cancer stroma, and during wound healing, suggesting involvement in pathological ECM remodeling.
Antibodies targeting COL14A1 are essential tools for studying its spatial distribution, expression levels, and functional roles. These antibodies are commonly used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize COL14A1 in tissues or cultured cells. They help identify its localization in skin, tendons, blood vessels, and musculoskeletal structures, providing insights into tissue-specific ECM dynamics. Researchers also utilize COL14A1 antibodies to explore its interactions with other ECM proteins and signaling pathways, particularly in contexts like fibrosis, tumor microenvironment modulation, and connective tissue disorders. Validated antibodies are critical for distinguishing COL14A1 from other FACIT collagens, ensuring specificity in experimental models. Recent studies highlight its potential as a biomarker or therapeutic target in diseases involving aberrant ECM remodeling.
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