| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Collagen alpha-1(XI) chain [Precursor]; COBA1; |
| Entrez GeneID | 1301; |
| WB Predicted band size | 181kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human Collagen XI alpha1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Collagen XI alpha抗体的3篇参考文献示例(内容基于模拟数据)：
1. **文献名称**：*"Collagen XI α1 facilitates cartilage development by regulating fibril assembly"*
**作者**：Yoshioka, H. et al.
**摘要**：研究通过免疫组化和Western blot分析COL11A1在软骨中的表达，发现其通过调控II型胶原纤维的组装影响软骨分化，抗体特异性验证显示其在发育中起关键作用。
2. **文献名称**：*"Role of collagen XI in extracellular matrix structure: Insights from antibody-based disruption studies"*
**作者**：Birk, D.E. & Trelstad, R.L.
**摘要**：利用胶原XI alpha抗体阻断功能，证实COLXI在维持胶原纤维直径和基质完整性中不可或缺，敲低模型显示纤维结构异常。
3. **文献名称**：*"COL11A1 mutations and antibody localization in zebrafish skeletal dysplasia models"*
**作者**：Asharani, P.V. et al.
**摘要**：在斑马鱼模型中，抗体验证COL11A1突变导致颅面骨骼畸形，免疫荧光显示突变体软骨胶原分布紊乱，提示其在骨骼发育中的保守功能。
4. **文献名称**：*"Altered collagen XI expression in osteoarthritis: A comparative immunohistochemical study"*
**作者**：Sztrolovics, R. et al.
**摘要**：对比骨关节炎患者与正常关节软骨，发现COL11A1抗体标记强度显著升高，提示其与疾病进展中基质重塑相关。
(注：以上文献为示例，实际引用需根据具体研究检索PubMed等数据库。)
Collagen XI alpha 1 (COL11A1) antibody is a tool used to study the α1 chain of type XI collagen, a minor fibrillar collagen critical for extracellular matrix (ECM) organization. Type XI collagen, composed of three α chains (α1. α2. α3), is closely associated with type II collagen in cartilage, vitreous humor, and other tissues, where it regulates fibril diameter and ECM stability. COL11A1 mutations are linked to skeletal dysplasias like Stickler syndrome, Marshall syndrome, and fibrochondrogenesis, characterized by craniofacial abnormalities, hearing loss, and joint issues. Additionally, COL11A1 overexpression is implicated in cancer progression, particularly in ovarian, gastric, and lung cancers, where it may promote epithelial-mesenchymal transition (EMT) and metastasis.
The COL11A1 antibody aids in detecting this protein in research applications such as immunohistochemistry, Western blotting, and immunofluorescence. It helps elucidate COL11A1's role in tissue development, disease mechanisms, and potential therapeutic targeting. Studies using this antibody have advanced understanding of how COL11A1 interacts with other collagens and growth factors to influence cell adhesion, tissue morphogenesis, and pathological processes. Its specificity and reliability make it valuable for both basic research and clinical investigations into connective tissue disorders and cancer biology.
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