| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dual specificity protein phosphatase 22; EC 3.1.3.48? EC 3.1.3.16; JNK-stimulatory phosphatase-1; JSP-1; Mitogen-activated protein kinase phosphatase x |
| Entrez GeneID | 56940; |
| WB Predicted band size | 21kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human DUSP22. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于DUSP22抗体的参考文献示例(内容为虚构，仅供格式参考)：
1. **文献名称**：DUSP22 Expression and Its Role in T-Cell Lymphoma Pathogenesis
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化(IHC)和Western blot技术，利用特异性DUSP22抗体分析其在T细胞淋巴瘤中的表达。结果显示，DUSP22表达缺失与JNK信号通路异常激活相关，提示其作为肿瘤抑制因子的潜在作用。
2. **文献名称**：Characterization of a Novel Monoclonal Antibody Against DUSP22 for Functional Studies
**作者**：Chen L, et al.
**摘要**：文章报道了一种高特异性小鼠抗人DUSP22单克隆抗体的开发与验证。该抗体成功用于免疫沉淀(IP)和免疫荧光(IF)，证实DUSP22在调控p38 MAPK磷酸化中的关键功能。
3. **文献名称**：DUSP22 Antibody-Based Detection in Autoimmune Disorders
**作者**：Gomez R, et al.
**摘要**：通过DUSP22抗体对患者外周血单核细胞进行流式细胞术分析，发现DUSP22在系统性红斑狼疮(SLE)中表达显著降低，提示其与自身免疫反应失调的关联。
4. **文献名称**：DUSP22 Antibody Cross-Reactivity Analysis Across Species
**作者**：Wang X, et al.
**摘要**：评估了多种商业DUSP22抗体在人类、小鼠和大鼠样本中的交叉反应性，筛选出适用于多物种研究的可靠抗体，并验证了其在蛋白定位研究中的实用性。
(注：以上文献为示例，实际引用需检索PubMed、Google Scholar等平台获取真实文献。)
The DUSP22 antibody is a crucial tool in studying dual-specificity phosphatase 22 (DUSP22), a member of the protein tyrosine phosphatase family. DUSP22. also known as JKAP or MKP-X, regulates mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating both tyrosine and serine/threonine residues on target proteins, including JNK, p38. and ERK. This enzyme plays a role in immune regulation, cell differentiation, proliferation, and apoptosis. Dysregulation of DUSP22 has been linked to diseases such as lymphoma, autoimmune disorders, and cancers, making it a focus of oncology and immunology research.
DUSP22 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect protein expression levels, localization, and activity in tissues or cell lysates. They are essential for investigating DUSP22's interaction partners, post-translational modifications, and role in signaling cascades. Researchers also utilize these antibodies to explore DUSP22's tumor-suppressive or oncogenic functions in specific contexts, particularly in T-cell lymphomas where chromosomal rearrangements involving DUSP22 are common.
Validation of DUSP22 antibodies is critical due to potential cross-reactivity with other phosphatases. High-quality antibodies are often verified using knockout cell lines or siRNA-mediated knockdown. Commercial DUSP22 antibodies are available in monoclonal and polyclonal formats, with applications spanning basic research, drug development, and diagnostic assays. Their utility in elucidating disease mechanisms underscores their importance in biomedical studies.
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