| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ARNT protein 2; Aryl hydrocarbon receptor nuclear translocator 2; ARNT2; KIAA0307; |
| Entrez GeneID | 9915; |
| WB Predicted band size | 79kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human ARNT2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ARNT2抗体的参考文献示例(仅供参考，具体文献需根据实际数据库检索确认)：
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1. **标题**: "ARNT2 regulates neuronal differentiation in the cerebral cortex"
**作者**: Hirose K, et al.
**摘要**: 研究通过免疫组化(IHC)和Western blot分析ARNT2蛋白在小鼠大脑皮层发育中的表达，发现其抗体特异性标记神经元前体细胞，提示ARNT2在神经分化中的关键作用。
2. **标题**: "Dimerization of ARNT2 with HIF-1α mediates hypoxia responses in renal cells"
**作者**: Sato Y, et al.
**摘要**: 利用ARNT2抗体验证其与HIF-1α的相互作用，通过免疫共沉淀(Co-IP)和免疫荧光(IF)证实ARNT2在肾细胞缺氧信号通路中的功能。
3. **标题**: "Loss of ARNT2 in zebrafish disrupts sensory neuron development"
**作者**: Woods C, et al.
**摘要**: 通过斑马鱼模型结合ARNT2抗体的Western blot和原位杂交，揭示ARNT2缺失导致感觉神经元异常，强调其在神经系统发育中的保守性。
4. **标题**: "Validation of a polyclonal ARNT2 antibody for human tissue studies"
**作者**: Müller R, et al.
**摘要**: 研究验证了一款多克隆ARNT2抗体的特异性，通过敲低实验和多种组织样本(如脑、肝)的免疫染色，证实其适用于人类蛋白检测。
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**注意**：以上为模拟示例，实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。建议使用关键词“ARNT2 antibody” + “Western blot/IHC/function”进一步查找。
The ARNT2 (Aryl Hydrocarbon Receptor Nuclear Translocator 2) antibody is a tool used to detect and study the ARNT2 protein, a member of the basic helix-loop-helix/Per-Arnt-Sim (bHLH-PAS) transcription factor family. ARNT2 shares structural homology with ARNT1 (also called HIF-1β), including conserved bHLH and PAS domains critical for dimerization and DNA binding. Unlike ARNT1. ARNT2 exhibits tissue-specific expression, predominantly in the brain, kidneys, and developing nervous system. It partners with other bHLH-PAS proteins, such as HIF-α (hypoxia-inducible factor) or SIM1. to regulate gene expression in response to hypoxia, neurodevelopment, and circadian rhythms.
ARNT2 is essential for neuronal survival, axon guidance, and hypothalamic development. Mutations or dysregulation of ARNT2 are linked to neurological disorders, including intellectual disabilities, autism spectrum disorders, and obesity-related phenotypes. The ARNT2 antibody is widely utilized in research applications like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, protein-protein interactions, and role in disease mechanisms. Specificity is a key consideration, as cross-reactivity with ARNT1 may occur due to sequence similarity. Validated antibodies help clarify ARNT2's distinct functions in cellular adaptation, developmental biology, and pathological conditions, making it a critical reagent for neuroscience and molecular studies.
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