| WB | 1/500-1/3000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein with KRAB and SCAN domains 13; Zinc finger protein 287; ZNF287; ZKSCAN13; |
| Entrez GeneID | 57336; |
| WB Predicted band size | 90kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human ZNF287. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF287抗体的3篇参考文献，内容基于假设性研究整理：
1. **文献名称**：*ZNF287 regulates tumor progression through transcriptional repression of tumor suppressors*
**作者**：Chen L, Wang Y, et al.
**摘要**：本研究利用ZNF287抗体进行免疫沉淀和染色质分析，揭示了ZNF287通过结合特定DNA序列抑制抑癌基因表达，促进结直肠癌进展的机制。
2. **文献名称**：*Expression and functional analysis of ZNF287 in pluripotent stem cell differentiation*
**作者**：Kim S, Zhang H, et al.
**摘要**：通过ZNF287抗体的Western blot和免疫荧光实验，发现该蛋白在干细胞分化过程中动态表达，并参与调控多能性基因的沉默。
3. **文献名称**：*Proteomic screening identifies ZNF287 as a novel biomarker in hepatocellular carcinoma*
**作者**：Gao R, Liu T, et al.
**摘要**：研究使用ZNF287抗体对肝癌组织进行免疫组化分析，证实其高表达与患者预后不良相关，提示其作为潜在诊断标志物的价值。
(注：以上文献为示例，实际研究中请通过学术数据库检索具体论文。)
The ZNF287 antibody is a research tool designed to target the ZNF287 protein, a member of the zinc finger protein (ZFP) family characterized by conserved Cys₂-His₂ (C2H2) zinc finger domains. ZNF287 is implicated in transcriptional regulation, chromatin remodeling, and epigenetic modulation, primarily through its ability to bind specific DNA sequences or interact with other regulatory proteins. It plays roles in cellular processes such as proliferation, differentiation, and apoptosis, with emerging links to cancer biology, including tumor suppression or oncogenic activities depending on context. Dysregulation of ZNF287 has been observed in certain cancers, suggesting its potential as a biomarker or therapeutic target.
The antibody, typically developed in rabbit or mouse hosts, enables detection and analysis of ZNF287 expression and localization via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Its applications span basic research into ZNF287's molecular functions, as well as translational studies exploring its role in disease mechanisms. Validation often includes specificity checks using knockout cell lines or siRNA-mediated knockdown to confirm signal absence. Researchers also utilize it to investigate post-translational modifications or protein-protein interactions involving ZNF287. As interest grows in zinc finger proteins' roles in genome regulation and disease, the ZNF287 antibody remains critical for elucidating its biological significance and therapeutic potential.
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