| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein Hox-A1; Hox-1F; HOXA1; HOX1F; |
| Entrez GeneID | 3198; |
| WB Predicted band size | 37kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human HOXA1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HOXA1抗体的3篇示例参考文献(注：内容为示例，非真实文献)：
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1. **文献名称**: *HOXA1 Antibody Validation in Developmental Disorders*
**作者**: Smith, J. et al. (2018)
**摘要**: 本研究验证了一种兔源多克隆HOXA1抗体的特异性，通过免疫印迹和免疫组化分析其在胚胎小鼠脑部的表达模式，证实HOXA1在神经管发育中的关键作用，并发现其异常表达与先天性颅面畸形相关。
2. **文献名称**: *HOXA1 Expression in Breast Cancer Metastasis*
**作者**: Zhang, Y. et al. (2020)
**摘要**: 使用HOXA1单克隆抗体进行免疫组化分析，发现HOXA1在乳腺癌组织中的高表达与淋巴结转移显著相关，提示其可能作为预后生物标志物，并通过siRNA实验验证了HOXA1对癌细胞侵袭的调控作用。
3. **文献名称**: *Characterization of a Novel HOXA1 Monoclonal Antibody*
**作者**: Lee, H. et al. (2016)
**摘要**: 报道了一种高特异性小鼠抗人HOXA1单克隆抗体的开发，经肽段竞争实验和质谱验证，成功应用于染色质免疫沉淀(ChIP)，揭示了HOXA1在干细胞分化过程中直接调控下游靶基因的机制。
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**备注**：以上文献为示例，实际引用时需通过学术数据库(如PubMed、Web of Science)检索真实存在的文章。建议结合具体研究领域(如发育生物学、癌症研究)进一步筛选。
The HOXA1 antibody is a crucial tool in studying the HOXA1 gene, a member of the homeobox (HOX) family of transcription factors. HOX genes are highly conserved across species and play pivotal roles in embryonic development, particularly in establishing body axis patterning and organogenesis. Specifically, HOXA1. located on chromosome 7p15.2. is involved in early neural development, craniofacial morphogenesis, and hindbrain segmentation. Dysregulation of HOXA1 has been linked to developmental disorders, cancers (e.g., leukemia, breast cancer), and neurological conditions like autism spectrum disorders.
The HOXA1 antibody detects and quantifies the HOXA1 protein, enabling researchers to investigate its expression, localization, and interactions in cellular and tissue contexts. It is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Studies utilizing this antibody have revealed HOXA1's role in cell differentiation, proliferation, and apoptosis, as well as its tissue-specific expression patterns. For instance, elevated HOXA1 levels in certain cancers correlate with tumor aggressiveness and poor prognosis, highlighting its potential as a therapeutic target or biomarker. In developmental biology, the antibody helps elucidate mechanisms underlying HOXA1-associated congenital anomalies. Its specificity and reliability make it indispensable for advancing both basic research and clinical applications.
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