Rabbit Polyclonal ANXA1(Ab-21) Antibody

The ANXA1 (Ab-21) antibody is a monoclonal antibody specifically targeting Annexin A1 (ANXA1), a 37-kDa calcium-dependent phospholipid-binding protein belonging to the annexin superfamily. ANXA1 plays critical roles in modulating inflammation, apoptosis, cell proliferation, and membrane repair. It is expressed in various tissues, including immune cells, epithelial cells, and endothelial cells, and is implicated in diseases such as cancer, autoimmune disorders, and neurodegenerative conditions. The Ab-21 clone, typically raised in mice, recognizes an epitope within the N-terminal domain (amino acids 1–13) of human ANXA1. a region essential for its anti-inflammatory and regulatory functions. This antibody is widely used in applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP) to study ANXA1 expression, localization, and interactions. Researchers utilize it to explore ANXA1's role in signaling pathways, such as the glucocorticoid-mediated anti-inflammatory response and its involvement in tumor progression or suppression. Validation studies often include knockout controls or peptide blocking to confirm specificity. The Ab-21 antibody has contributed to elucidating ANXA1's dual roles in promoting resolution of inflammation and regulating cellular processes in pathological states, making it a valuable tool in both basic and translational research.