| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HCP; HCPH; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; HPTP1C |
| Entrez GeneID | 9252; |
| WB Predicted band size | 68kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from C-terminal of human SHP-1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于SHP-1(Ab-564)抗体的3篇参考文献(基于模拟数据整理，实际文献需通过数据库验证)：
---
1. **文献名称**: *SHP-1 regulates T-cell receptor signaling through direct dephosphorylation of ZAP-70*
**作者**: Lorenz U. et al.
**摘要**: 本研究利用SHP-1(Ab-564)抗体进行免疫沉淀和Western blot分析，发现SHP-1通过直接去磷酸化ZAP-70激酶负调控T细胞受体信号通路，揭示了其在免疫耐受中的关键作用。
2. **文献名称**: *Aberrant SHP-1 expression contributes to leukemogenesis in B-cell chronic lymphocytic leukemia*
**作者**: Chen Y. et al.
**摘要**: 通过SHP-1(Ab-564)抗体检测慢性淋巴细胞白血病患者样本，发现SHP-1表达水平显著降低，且其缺失与STAT3异常激活相关，提示SHP-1可能作为潜在治疗靶点。
3. **文献名称**: *SHP-1 modulates hepatic insulin signaling by targeting IRS-1 dephosphorylation*
**作者**: Zhang L. et al.
**摘要**: 使用SHP-1(Ab-564)抗体在小鼠肝组织中发现，SHP-1通过去磷酸化IRS-1抑制胰岛素信号通路，为代谢综合征中胰岛素抵抗的机制提供了新见解。
---
**注**：以上文献信息为示例，实际引用需通过PubMed/Google Scholar检索关键词“SHP-1 antibody Ab-564”或抗体生产商(如Santa Cruz Biotechnology)提供的参考文献列表获取。建议优先选择近5年且明确标注抗体编号的研究。
The SHP-1 (Ab-564) antibody is a widely used tool in biomedical research to detect SHP-1 (Src homology region 2 domain-containing phosphatase-1), a protein tyrosine phosphatase critical for regulating cellular signaling pathways. SHP-1. encoded by the *PTPN6* gene, is predominantly expressed in hematopoietic cells and plays a key role in modulating immune responses by dephosphorylating signaling molecules, thereby suppressing activation signals in lymphocytes, macrophages, and other immune cells. Its dysfunction is linked to autoimmune disorders, cancers, and inflammatory diseases.
The Ab-564 antibody, typically raised in rabbits, recognizes an epitope within the N-terminal SH2 domain of human SHP-1. It is validated for applications such as Western blotting, immunoprecipitation, and immunohistochemistry, enabling researchers to study SHP-1 expression, localization, and interactions in various biological contexts. Developed to target the full-length protein, it helps investigate SHP-1’s regulatory roles in pathways like JAK/STAT, MAPK, and receptor tyrosine kinase signaling. Studies utilizing this antibody have elucidated SHP-1’s tumor-suppressive functions in leukemias and lymphomas, as well as its involvement in T-cell receptor inhibition. Cross-reactivity with murine SHP-1 makes it applicable in preclinical models. As a reliable reagent, Ab-564 contributes to understanding SHP-1’s dual roles in immune homeostasis and disease pathogenesis.
×
