Rabbit Polyclonal IKK-γ(Ab-85) Antibody

The IKK-γ (Ab-85) antibody is a specific tool used to detect the gamma subunit of the inhibitor of nuclear factor kappa-B kinase (IKK) complex, also known as NF-κB essential modulator (NEMO). IKK-γ is a regulatory component of the IKK complex, which plays a central role in activating the NF-κB signaling pathway. This pathway is critical for regulating immune responses, inflammation, and cell survival by controlling the transcription of genes involved in these processes. IKK-γ (NEMO) lacks kinase activity but is essential for assembling and stabilizing the IKK complex, which includes catalytic subunits IKK-α and IKK-β. Phosphorylation at specific residues, such as Ser85. can modulate its function in signaling. The Ab-85 antibody typically targets this phosphorylated form (e.g., pSer85), enabling researchers to study post-translational modifications linked to pathway activation. It is widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate NF-κB signaling dynamics in conditions like inflammatory diseases, cancer, and immune disorders. Validated for specificity, this antibody helps elucidate mechanisms of IKK complex regulation and its role in disease pathogenesis.