Rabbit Polyclonal AurB/C(Ab-202/175) Antibody

Aurora kinase B (AurB) and Aurora kinase C (AurC) are serine/threonine kinases belonging to the Aurora kinase family, which play critical roles in regulating mitotic progression. AurB, the best-characterized member, is a chromosomal passenger protein essential for chromosome alignment, kinetochore-microtubule attachment, and cytokinesis. AurC shares high structural and functional similarity with AurB, particularly in its kinase domain, and is thought to compensate for AurB in certain contexts, though its expression is more restricted, primarily to germ cells and some cancer types. The AurB/C (Ab-202/175) antibody is a monoclonal antibody that recognizes both AurB and AurC isoforms. Clone-specific identifiers (e.g., Ab-202 and Ab-175) often refer to distinct clones validated for detecting these kinases in applications like Western blotting, immunofluorescence, or immunohistochemistry. These antibodies are widely used to study mitotic regulation, checkpoint control, and genomic instability in cancer, where Aurora kinases are frequently overexpressed and linked to poor prognosis. Researchers also employ them to explore therapeutic targeting of Aurora kinases, as inhibitors are under investigation for cancer treatment. Validation of clone specificity is critical, as cross-reactivity with other Aurora family members (e.g., Aurora A) or non-specific binding can occur depending on experimental conditions.