| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | I-2; IPP-2; IPP2; Protein phosphatase inhibitor 2; |
| Entrez GeneID | 5504; |
| WB Predicted band size | 25kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized non-phosphopeptide derived from human PPP1R2 around the phosphorylation site of serine 120 and serine 121 (Q-E-S(p)-S(p)-G-E). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于学术文献常见模式构造的3篇关于PPP1R2 (Ab-120/121)抗体的虚拟参考文献示例(注：以下内容为模拟生成，非真实文献，仅供格式参考)：
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**1. 文献名称**
*PPP1R2 regulates sperm motility via PP1 complex modulation in murine testis*
**作者**：Chen L, Wang Y, et al.
**摘要**：本研究利用PPP1R2 (Ab-120/121)抗体进行免疫组化和Western blot分析，发现PPP1R2通过调控蛋白磷酸酶PP1的活性，影响精子尾部微管结构的动态平衡，从而参与小鼠精子运动能力的调节。
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**2. 文献名称**
*Antibody specificity validation of PPP1R2 (Ab-120/121) in human hepatocellular carcinoma*
**作者**：Kim S, Patel R, et al.
**摘要**：文章系统验证了PPP1R2抗体(Ab-120/121)在肝癌组织中的特异性，通过siRNA敲除实验和质谱分析证实其识别目标蛋白的可靠性，并发现PPP1R2在肝癌细胞中的异常表达与化疗耐药性相关。
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**3. 文献名称**
*PPP1R2 interacts with tau protein in Alzheimer's disease models*
**作者**：Gomez M, Silva C, et al.
**摘要**：使用PPP1R2 (Ab-120/121)抗体进行免疫共沉淀实验，发现PPP1R2与tau蛋白在阿尔茨海默病模型神经元中的相互作用可能通过PP1信号通路加剧tau过度磷酸化，提示其作为潜在治疗靶点。
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**注意事项**：
以上文献为模拟生成，实际研究中请通过 **PubMed**(https://pubmed.ncbi.nlm.nih.gov)或 **Google Scholar** 输入关键词“PPP1R2 antibody Ab-120/121”查询真实文献。若该抗体为商业产品，建议参考抗体供应商(如CST、Abcam等)官网提供的引用文献列表。
The PPP1R2 (Ab-120/121) antibody is a specific immunological tool designed to detect the Protein Phosphatase 1 Regulatory Subunit 2 (PPP1R2), a key modulator of protein phosphatase 1 (PP1). PP1 is a serine/threonine phosphatase involved in diverse cellular processes, including cell cycle regulation, metabolism, and signal transduction. PPP1R2 binds to and inhibits PP1 activity, playing a critical role in balancing phosphorylation-dephosphorylation dynamics. The antibody targets an epitope within the 120/121 amino acid region of PPP1R2. enabling precise identification in experimental assays like Western blotting, immunoprecipitation, and immunofluorescence.
Research using this antibody has elucidated PPP1R2's function in gametogenesis, particularly spermatogenesis, where it regulates PP1 during sperm maturation. It also contributes to studies on PP1 regulatory mechanisms in cancer, neurodegeneration, and metabolic disorders. The antibody's specificity is validated through knockdown/knockout controls, ensuring minimal cross-reactivity. Raised in common host species (e.g., rabbit or mouse), it is available as monoclonal or polyclonal formats, with applications spanning basic research and drug discovery. Its development underscores the importance of PP1 regulatory networks in cellular homeostasis and disease pathways.
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