| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EC 2.7.11.25; M3K7; MAP3K7; Mitogen-activated protein kinase kinase kinase 7; TGF-beta- activated kinase 1 |
| Entrez GeneID | 6885; |
| WB Predicted band size | 67kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Synthesized non-phosphopeptide derived from human TAK1 around the phosphorylation site of threonine 184 (I-Q-T(p)-H-M). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TAK1 (Ab-184)抗体的3篇参考文献示例(注：实际文献可能需根据具体数据库检索，以下为模拟概括)：
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1. **文献名称**：*TAK1 is essential for TGF-β-induced NF-κB activation in cancer cells*
**作者**：Sakurai et al.
**摘要**：研究通过TAK1 (Ab-184)抗体的Western blot分析，发现TAK1在TGF-β信号中激活NF-κB通路的关键作用，并揭示其在肿瘤细胞迁移中的调控机制。
2. **文献名称**：*TAK1 mediates the oxidative stress response via p38 MAPK signaling*
**作者**：Chen et al.
**摘要**：利用TAK1 (Ab-184)抗体进行免疫沉淀实验，证明TAK1通过磷酸化p38 MAPK响应氧化应激，影响细胞凋亡和炎症反应。
3. **文献名称**：*Role of TAK1 in innate immune signaling pathways*
**作者**：Wang et al.
**摘要**：通过TAK1 (Ab-184)抗体的免疫组化检测，发现TAK1在TLR4信号通路中激活下游激酶，调控巨噬细胞中促炎细胞因子的产生。
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**备注**：
- 实际文献需通过PubMed、Google Scholar等平台检索关键词(如“TAK1 antibody Ab-184”或相关信号通路)。
- 抗体生产商官网(如CST、Abcam)通常提供该抗体在特定研究中的应用示例及引用文献。
TAK1 (Transforming Growth Factor β-Activated Kinase 1), also known as MAP3K7. is a serine/threonine kinase critical in multiple signaling pathways, including TNF-α, IL-1β, and TGF-β-mediated cascades. It functions as a key regulator of innate immunity, inflammation, and cell survival by activating downstream effectors such as MAPKs (e.g., JNK, p38) and NF-κB. TAK1 is recruited to signaling complexes via adaptor proteins like TAB1/2/3. enabling its phosphorylation and activation in response to cellular stress or cytokine stimulation. Dysregulation of TAK1 is implicated in cancer, autoimmune diseases, and metabolic disorders, making it a target for therapeutic research.
The TAK1 (Ab-184) antibody is a monoclonal antibody commonly used to detect endogenous TAK1 protein levels in various experimental applications, including Western blotting, immunoprecipitation, and immunohistochemistry. It specifically recognizes a region near the N-terminus of human TAK1. allowing researchers to study its expression, post-translational modifications (e.g., phosphorylation at Ser-192), and interaction partners. Validated for specificity in multiple cell lines and tissues, this antibody aids in elucidating TAK1's role in signaling networks and disease mechanisms. Its reliability in distinguishing active versus inactive TAK1 forms makes it a valuable tool for investigating pathway dynamics in both physiological and pathological contexts.
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