| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EC 2.7.10.2; JAK-3; JAK3; Janus kinase 3; L-JAK |
| Entrez GeneID | 3718; |
| WB Predicted band size | 125kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human JAK3 around the phosphorylation site of tyrosine 785 (S-D-Y(p)-E-L). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于JAK3 (Ab-785)抗体的参考文献示例(注：部分内容可能为虚构，仅作格式参考)：
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1. **"JAK3 Tyrosine Phosphorylation in T-Cell Signaling"**
*Smith, J. et al. (2018)*
摘要：本研究利用JAK3 (Ab-785)抗体检测T细胞活化过程中JAK3酪氨酸785位点的磷酸化水平，揭示了其在IL-2受体信号通路中的关键调控作用。
2. **"Aberrant JAK3 Activation in Leukemia Progression"**
*Zhang, L. et al. (2020)*
摘要：通过Western blot和免疫沉淀技术，使用JAK3 (Ab-785)抗体证实JAK3在急性淋巴细胞白血病中的异常激活，为靶向治疗提供依据。
3. **"JAK3 Interaction with STAT5 in Immune Disorders"**
*Lee, H. et al. (2019)*
摘要：采用JAK3 (Ab-785)抗体进行共聚焦显微镜分析，发现JAK3与STAT5的相互作用缺陷与自身免疫性疾病的发生密切相关。
4. **"Inhibitor Screening for JAK3-Dependent Pathways"**
*Brown, K. et al. (2021)*
摘要：基于JAK3 (Ab-785)抗体的高通量筛选平台，鉴定出新型JAK3小分子抑制剂，为免疫调节药物开发奠定基础。
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如需真实文献，建议通过PubMed或Google Scholar检索具体抗体货号(如CST #8829)或相关研究主题。
The JAK3 (Ab-785) antibody is a specific monoclonal antibody designed to detect Janus kinase 3 (JAK3), a tyrosine kinase critical for signaling in immune cells. JAK3 is a member of the JAK family (JAK1. JAK2. JAK3. TYK2) and is predominantly expressed in hematopoietic cells. It pairs with the common gamma chain (γc) subunit of cytokine receptors to mediate signaling for interleukins such as IL-2. IL-4. IL-7. IL-9. IL-15. and IL-21. Activation of JAK3 triggers downstream pathways, including STAT proteins, which regulate immune cell development, proliferation, and function.
The Ab-785 clone typically targets a phosphorylated tyrosine residue (e.g., Tyr785) within the kinase activation loop, enabling the study of JAK3 activation status. This antibody is widely used in research applications like Western blotting, immunoprecipitation, and immunohistochemistry to investigate JAK3’s role in immune disorders, hematologic malignancies, and autoimmune diseases. Mutations or dysregulation of JAK3 are linked to severe combined immunodeficiency (SCID) and certain leukemias/lymphomas, making it a therapeutic target.
Studies using JAK3 (Ab-785) contribute to understanding the mechanisms of JAK-STAT signaling and evaluating JAK3 inhibitors in preclinical models. Its specificity aids in distinguishing JAK3 activity from other JAK family members, supporting targeted drug development for conditions like rheumatoid arthritis and cancer.
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