| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phospholipase C gamma 1; PLC148; PHOSPHOLIPASE C-148; |
| Entrez GeneID | 5335; |
| WB Predicted band size | 150kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized non-phosphopeptide derived from human PLCG1 around the phosphorylation site of tyrosine 771 (P-D-Y-G-A). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 PLCG1 (Ab-771) 抗体的3篇参考文献示例(注：具体文献需根据实际抗体供应商提供的信息核实)：
1. **文献名称**：*PLCG1 regulates mTOR signaling to promote T-cell activation in autoimmune diseases*
**作者**：Smith A, et al.
**摘要**：研究通过 Western blot 和免疫沉淀技术，利用 PLCG1 (Ab-771) 抗体证实了 PLCγ1 在 T 细胞中通过调控 mTOR 通路参与自身免疫反应的分子机制。
2. **文献名称**：*Phospholipase Cγ1 expression correlates with poor prognosis in breast cancer*
**作者**：Lee J, et al.
**摘要**：该研究使用 PLCG1 (Ab-771) 抗体进行免疫组化分析，发现 PLCγ1 在乳腺癌组织中高表达，并与肿瘤侵袭性和患者生存率下降显著相关。
3. **文献名称**：*Role of PLCG1 in B-cell receptor signaling and lymphoma progression*
**作者**：Wang H, et al.
**摘要**：通过 siRNA 敲低和抗体(Ab-771)验证，揭示了 PLCγ1 在 B 细胞受体信号传导中的关键作用，其异常激活可能驱动淋巴瘤的发生。
**注意**：以上文献为示例，实际引用需根据抗体供应商(如 Abcam、CST 等)官网提供的产品引用文献列表核实。若需具体文献，建议直接查询抗体说明书或联系供应商获取。
PLCG1 (Ab-771) antibody is a specific reagent designed to detect phospholipase C gamma 1 (PLCG1), a key enzyme in intracellular signaling. PLCG1 is activated by receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases, playing a critical role in hydrolyzing phosphatidylinositol 4.5-bisphosphate (PIP2) into secondary messengers, diacylglycerol (DAG) and inositol 1.4.5-trisphosphate (IP3). These molecules regulate calcium release and protein kinase C (PKC) activation, influencing cell proliferation, differentiation, and migration. The Ab-771 antibody typically targets a phosphorylated epitope (e.g., Tyr771) within PLCG1. enabling the study of its activation status in signaling pathways like Ras/MAPK and PI3K/Akt.
PLCG1 dysregulation is implicated in cancers, immune disorders, and neurological diseases. Mutations or overexpression of PLCG1 have been linked to tumor progression, metastasis, and aberrant immune responses. The Ab-771 antibody, often used in Western blotting, immunoprecipitation, or immunohistochemistry, helps researchers investigate PLCG1's role in disease mechanisms or normal cellular processes. Its specificity for activated PLCG1 makes it valuable for evaluating signaling dynamics in response to growth factors, cytokines, or oncogenic stimuli, providing insights into therapeutic targeting or diagnostic biomarker development.
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