Rabbit Polyclonal GR(Ab-211) Antibody

The GR (Ab-211) antibody is a monoclonal antibody specifically designed to target the glucocorticoid receptor (GR), a nuclear receptor encoded by the *NR3C1* gene. GR is a critical mediator of glucocorticoid signaling, regulating gene expression in response to stress, immune responses, metabolism, and homeostasis. The Ab-211 clone recognizes an epitope within the N-terminal domain of human GR, enabling detection of both alpha (active) and beta (inactive) isoforms. It is widely used in applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study GR expression, localization, and function in various tissues and disease models, including cancer, inflammation, and metabolic disorders. Developed and validated for high specificity and sensitivity, this antibody has become a key tool in research exploring glucocorticoid signaling pathways, receptor dynamics (e.g., nuclear translocation), and therapeutic resistance mechanisms. Its cross-reactivity with rodent GR makes it applicable in preclinical studies. Suppliers often provide detailed validation data, including knockout/knockdown controls, ensuring reliability in experimental settings. As dysregulated GR signaling is implicated in numerous pathologies, GR (Ab-211) remains essential for advancing mechanistic and translational studies in endocrinology, oncology, and immunology.