| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1:1000-1:2000 | Human,Mouse,Rat |
| Aliases | Elaxin/insulin-like family peptide receptor 4, GPR100; RLN3R2; RXFPR4; GPCR142 |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide corresponding to a region derived from 360-374 amino acids of human elaxin/insulin-like family peptide receptor 4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RXFP4抗体的模拟参考文献示例(非真实文献，仅供参考格式和内容)：
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1. **文献名称**: *Development and Characterization of a Novel Anti-RXFP4 Monoclonal Antibody for Immunohistochemical Analysis*
**作者**: Zhang, Y. et al.
**摘要**: 本研究报道了一种特异性识别RXFP4的单克隆抗体的开发与验证。通过免疫组化实验，该抗体成功用于检测多种癌症组织中RXFP4的蛋白表达水平，证实其在肿瘤微环境中的潜在作用。
2. **文献名称**: *RXFP4 Antibody-Based Profiling Reveals Receptor Localization in Metabolic Tissues*
**作者**: Johnson, R.L. et al.
**摘要**: 利用高亲和力RXFP4多克隆抗体，研究者揭示了该受体在脂肪细胞和肠道中的分布特征，并探讨了其在能量代谢和食欲调控中的功能机制。
3. **文献名称**: *Structural Insights into RXFP4 Activation Using Conformation-Specific Antibodies*
**作者**: Müller, C. et al.
**摘要**: 通过构象特异性抗体结合冷冻电镜技术，本研究解析了RXFP4与其配体松弛素的相互作用机制，为靶向该受体的药物设计提供了结构基础。
4. **文献名称**: *Validation of a Commercial RXFP4 Antibody for Flow Cytometry Applications*
**作者**: Lee, S. et al.
**摘要**: 评估了市售RXFP4抗体在流式细胞术中的性能，确认其适用于免疫细胞表面受体定量分析，为炎症和免疫疾病研究提供了可靠工具。
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如需真实文献，建议通过PubMed、Google Scholar等平台搜索关键词“RXFP4 antibody”或“anti-RXFP4”获取最新研究。
The RXFP4 antibody is a research tool designed to target the Relaxin Family Peptide Receptor 4 (RXFP4), a class A G protein-coupled receptor (GPCR) belonging to the relaxin receptor family. RXFP4 binds its endogenous ligand, insulin-like peptide 5 (INSL5), which is primarily expressed in peripheral tissues such as the colon, pancreas, and specific brain regions. The INSL5/RXFP4 signaling axis is implicated in regulating energy metabolism, appetite, and glucose homeostasis, with studies suggesting its activation during fasting states to promote adaptive behaviors like food-seeking. Dysregulation of this pathway has been linked to metabolic disorders and cancers, including neuroendocrine tumors and colorectal cancer, where RXFP4 overexpression may drive tumor growth and metastasis.
RXFP4 antibodies are critical for detecting receptor expression, localizing it in tissues, and studying its functional roles in physiological and pathological contexts. They enable techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding in the exploration of RXFP4's signaling mechanisms and interactions. Additionally, these antibodies hold therapeutic potential, as RXFP4 is considered a biomarker and drug target for cancers and metabolic diseases. Researchers also use them to evaluate the efficacy of RXFP4-targeted therapies, such as monoclonal antibodies or small-molecule inhibitors. Overall, RXFP4 antibodies serve as essential tools for unraveling the receptor's biology and advancing translational applications.
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