| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase PLSTIRE |
| Entrez GeneID | 1021; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Peptide sequence around aa.22~26 (G-A-Y-G-K) derived from Human CDK6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CDK6(Ab-24)抗体的3篇参考文献示例(注：文献为模拟示例，实际需根据具体数据库检索验证)：
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1. **文献名称**：*CDK6 phosphorylation regulates cell cycle progression in breast cancer*
**作者**：Smith A, et al.
**摘要**：本研究利用CDK6(Ab-24)抗体进行免疫沉淀和Western blot分析，揭示了CDK6在乳腺癌细胞周期调控中的关键磷酸化位点，并证明其与肿瘤增殖的相关性。
2. **文献名称**：*Targeting CDK6 in glioblastoma: Insights from antibody-based inhibition*
**作者**：Chen L, et al.
**摘要**：通过CDK6(Ab-24)抗体的免疫组化实验，作者发现CDK6在胶质母细胞瘤中高表达，并通过体外功能实验验证其作为治疗靶点的潜力。
3. **文献名称**：*Role of CDK6 in T-cell acute lymphoblastic leukemia pathogenesis*
**作者**：Rodriguez M, et al.
**摘要**：本研究采用CDK6(Ab-24)抗体进行流式细胞术和ChIP-seq分析，阐明了CDK6通过调控转录复合物影响T-ALL发展的分子机制。
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**提示**：实际文献检索建议通过PubMed、Google Scholar或抗体供应商(如CST、Abcam)的引用列表，输入关键词“CDK6 antibody Ab-24”或产品编号(如#12345)获取准确信息。
**Background of CDK6 (Ab-24) Antibody**
CDK6 (Cyclin-Dependent Kinase 6) is a serine/threonine kinase critical for cell cycle progression, primarily regulating the G1-to-S phase transition through its interaction with D-type cyclins. It phosphorylates retinoblastoma (Rb) protein, releasing transcription factors to drive DNA replication. Dysregulation of CDK6 is implicated in cancers, particularly leukemias and solid tumors, due to its role in promoting uncontrolled proliferation.
The CDK6 (Ab-24) antibody is a monoclonal antibody specifically designed to recognize human CDK6. It targets a conserved epitope within the kinase domain, enabling detection of endogenous CDK6 in various experimental applications, including Western blotting, immunoprecipitation, and immunofluorescence. Validated for specificity and sensitivity, this antibody helps researchers study CDK6 expression, function, and its interaction with regulatory partners or inhibitors.
CDK6 (Ab-24) is widely used in cancer research to explore therapeutic strategies targeting cell cycle dysregulation, such as CDK4/6 inhibitor studies. Its reliability in distinguishing CDK6 from homologous kinases (e.g., CDK4) makes it a valuable tool for mechanistic and translational investigations in oncology and cell biology.
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