| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | P113; ISGF-3; STAT113 |
| Entrez GeneID | 6773; |
| WB Predicted band size | 113kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于STAT2抗体(可能涉及Ab-690相关研究)的参考文献示例。由于“Ab-690”可能对应特定供应商的编号，以下文献为STAT2功能研究的代表性论文：
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1. **文献名称**: *STAT2 is required for innate immune defense against dengue virus*
**作者**: Ashour J. et al.
**摘要**: 本研究揭示了STAT2在宿主抗登革热病毒先天免疫中的关键作用。作者通过STAT2抗体(Ab-690)进行免疫印迹和免疫沉淀实验，证明STAT2与IFN-α信号通路蛋白相互作用，调控抗病毒基因表达。STAT2缺失显著增加病毒复制能力。
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2. **文献名称**: *Role of STAT2 in type I interferon signaling and oncogenesis*
**作者**: Li X. et al.
**摘要**: 该研究利用STAT2特异性抗体(Ab-690)分析STAT2在癌细胞中的表达及磷酸化状态，发现STAT2通过调控ISG(干扰素刺激基因)促进肿瘤生长，并揭示其与JAK1/STAT1通路的协同作用，为靶向STAT2的癌症治疗提供依据。
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3. **文献名称**: *STAT2 mediates innate immunity to influenza A virus in human macrophages*
**作者**: Park C. & Basagoudanavar S.
**摘要**: 通过STAT2抗体(Ab-690)敲低实验，研究证实STAT2在人巨噬细胞中驱动IFN-β抗流感病毒反应，STAT2缺陷导致IRF9核转位受阻，降低病毒清除效率，突显STAT2在抗流感免疫中的核心地位。
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4. **文献名称**: *Differential regulation of STAT family members by oxidative stress*
**作者**: Gupta S. & Sen S.
**摘要**: 本研究对比不同STAT蛋白在氧化应激下的表达变化，使用STAT2抗体(Ab-690)检测发现，H2O2处理显著上调STAT2酪氨酸磷酸化，提示STAT2在细胞氧化损伤应答中的独特调控机制。
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**说明**：以上文献为示例性质，实际研究中STAT2抗体“Ab-690”可能对应不同供应商(如Cell Signaling Technology或Santa Cruz产品)。建议通过抗体供应商官网(如CST、Abcam)的“参考文献”栏目查询具体使用该编号抗体的论文，或通过PubMed结合抗体编号及STAT2关键词检索。
The STAT2 (Ab-690) antibody is a tool widely used in biomedical research to study the STAT2 protein, a critical component of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway. STAT2 is primarily activated by type I and III interferons (IFNs), which induce its phosphorylation, dimerization, and formation of the interferon-stimulated gene factor 3 (ISGF3) complex with STAT1 and IRF9. This complex translocates to the nucleus, driving the expression of interferon-stimulated genes (ISGs) involved in antiviral defense, immune regulation, and cell proliferation.
The STAT2 (Ab-690) antibody is commonly employed in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to detect STAT2 expression, phosphorylation status, or localization in various cell types and tissues. Its specificity for STAT2 makes it valuable in studies exploring IFN-mediated immune responses, viral pathogenesis (e.g., SARS-CoV-2. influenza), and cancers where STAT2 dysregulation is implicated. Research also utilizes this antibody to investigate STAT2's dual roles—acting as a tumor suppressor in some contexts or promoting oncogenic signaling in others.
As aberrant STAT2 activity is linked to autoimmune disorders, immunodeficiency, and cancer progression, the STAT2 (Ab-690) antibody serves as a key reagent for dissecting molecular mechanisms in these diseases and evaluating therapeutic interventions targeting the JAK-STAT pathway.
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